Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

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2024年6月20日

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Mandy Fisher,
Hope A. Weiler,
Jordan R. Kuiper,
Michael Borghese,
Jessie P. Buckley,
Robin Shutt,
Jillian Ashley-Martin,
Anita Subramanian,
Tye E. Arbuckle,
Beth K. Potter,
Julian Little,
Anne-Sophie Morisset,
Anne Marie Jukic

摘要

Purpose of Review

To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.

Recent Findings

We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings.

Summary

Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.