<p>To investigate the dynamic regulation of hippocampal CA3 ripple oscillations by athorny pyramidal cells (aPCs), we conducted a comparative analysis of two neural network models of the CA3 region: a conventional model composed solely of thorny pyramidal cells (tPCs) and a more complex model incorporating both burst-firing aPCs and tPCs. The obtained results demonstrate that aPCs significantly reduce the threshold of synaptic coupling required for ripple generation. Furthermore, the inclusion of aPCs enhances ripple power and frequency while shortening the duration of ripple events. These effects depend critically on both the intrinsic burst-firing properties of aPCs and their synaptic coupling strength within the network. Our results uncover a previously unidentified mechanism in which aPCs modulate ripple oscillations by coordinating synaptic dynamics through spontaneous bursting activity. This study provides new insights into the functional organization of the CA3 microcircuit and highlights the pivotal role of aPCs in regulating hippocampal network dynamics.</p>