<p>This paper investigates the predefined-time event-triggered leader–follower consensus control problem for second-order multiagent systems under the influence of actuator faults, input saturation and external disturbances. First, a neighbor-based distributed estimator is constructed to estimate the leader’s information in a predefined time. Next, a novel auxiliary system is tactfully developed to access the compensation signals, ensuring that the control inputs satisfy the amplitude constraints. Then, an adaptive predefined-time disturbance observer is presented for estimating the lumped disturbances consisting of actuator faults and external disturbances. Furthermore, a novel integral sliding mode-based predefined-time event-triggered control scheme is established to realize the predefined-time distributed consensus control of MAS. Finally, numerical simulations demonstrate the effectiveness of the proposed scheme.</p>