<p>Inspired by the silent flight of owls, the serrated trailing edge structure of owls was introduced into the design of centrifugal pump impellers. This paper uses numerical methods and experiments to explore the impact of serrated trailing edge structures on the centrifugal pump performance and dynamic performance. Four impellers with different structures are created, respectively: the original impeller (T0), two-tooth impeller (T2), three-tooth impeller (T3), and five-tooth impeller (T5). The research results show that the head of impellers with a serrated trailing edge decreases, and the efficiency slightly decreases around the design conditions. The primary frequency is blade passing frequency (BPF) at different measuring points. Under design flow conditions, the serrated trailing edge impeller can reduce the intensity of pressure pulsation and BPF amplitude at most measurement points. Through vibration tests, there is also a significant reduction in blade frequency vibration levels at 1/3 octave band. The study introduces the serrated structure into the centrifugal pump impellers, which can reduce pressure pulsation and vibration intensity at BPF under design conditions.</p>