Purpose <p>The present systematic review aimed to investigate the impact of dental treatment for molar-incisor hypomineralisation (MIH) on the oral health-related quality of life (OHRQoL) in children.</p> Methods <p>A literature search was conducted in four databases (Medline/PubMed, Embase, Scopus, and Google Scholar). Two independent reviewers selected studies amongst children with MIH who had received dental treatment, with OHRQoL assessed both before and after interventions. Data were critically summarised following the Synthesis Without Meta-analysis guideline. The risk of bias was assessed using the Cochrane ROB-2 tool, and the certainty of evidence was assessed using the GRADE approach.</p> Results <p>From the initial 460 identified studies, five were included. These studies included a total of 491 children aged 3–16 years (258 females and 233 males), each with at least one MIH-affected tooth. Qualitative synthesis indicated an improvement in OHRQoL in children following MIH treatment. However, the included studies exhibited potential biases in specific domains, and the certainty of evidence was rated as low.</p> Conclusion <p>Treatment of MIH-affected teeth positively impacts the OHRQoL of children.</p>