Scholarlink

Purpose <p>To assess the association between non-syndromic cleft lip and/or palate (NSCL/P) and developmental defects of enamel (DDE), including the DDE subtypes, such as molar-incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM).</p> Methods <p>This cross-sectional study with a comparison group included individuals with and without NSCL/P (“NSCL/P group” and “control group,” respectively). The NSCL/P group was recruited from a specialised craniofacial centre, and the control group was randomly selected from a population-based sample of schoolchildren, in a 1:2 ratio. DDEs were assessed by calibrated examiners through clinical examination. Associations between NSCL/P and DDE were analysed using univariate Poisson regression with robust variance (<i>α = </i>5%), and comparisons between subtypes included Bonferroni-adjusted <i>p</i> values to account for multiple testing.</p> Results <p>The sample included 164 children with NSCL/P and 328 controls (mean age = 8.09 ± 1.39&#xa0;years). DDEs were more prevalent in the NSCL/P group (76.8%) than in controls (66.2%) (<i>p &lt; </i>0.01). Hypoplasia, demarcated opacities, and MIH/HSPM were significantly more frequent in the NSCL/P group (<i>p &lt; </i>0.01). Fluorosis was significantly more prevalent in the control group (<i>p &lt; </i>0.01). MIH was the most frequent DDE in the NSCL/P group (29.3%). DDEs in the anterior teeth were significantly associated with cleft laterality, being most frequent in bilateral clefts (<i>p &lt; </i>0.01).</p> Conclusion <p>Children with NSCL/P have a higher prevalence of DDE than those without clefts. MIH was the most prevalent defect observed in this population, highlighting its clinical relevance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cleft lip and palate are associated with a higher prevalence of molar-incisor hypomineralisation: a cross-sectional study with a comparison group

  • 期刊论文

  • 发表日期：

    2025年9月1日

查看全文
  • Gabriela Fonseca-Souza,
  • Vitória Tessari,
  • Tatiane Rolim,
  • Luíse Gomes-Souza,
  • Juliana Feltrin-Souza

摘要

Purpose

To assess the association between non-syndromic cleft lip and/or palate (NSCL/P) and developmental defects of enamel (DDE), including the DDE subtypes, such as molar-incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM).

Methods

This cross-sectional study with a comparison group included individuals with and without NSCL/P (“NSCL/P group” and “control group,” respectively). The NSCL/P group was recruited from a specialised craniofacial centre, and the control group was randomly selected from a population-based sample of schoolchildren, in a 1:2 ratio. DDEs were assessed by calibrated examiners through clinical examination. Associations between NSCL/P and DDE were analysed using univariate Poisson regression with robust variance (α = 5%), and comparisons between subtypes included Bonferroni-adjusted p values to account for multiple testing.

Results

The sample included 164 children with NSCL/P and 328 controls (mean age = 8.09 ± 1.39 years). DDEs were more prevalent in the NSCL/P group (76.8%) than in controls (66.2%) (p < 0.01). Hypoplasia, demarcated opacities, and MIH/HSPM were significantly more frequent in the NSCL/P group (p < 0.01). Fluorosis was significantly more prevalent in the control group (p < 0.01). MIH was the most frequent DDE in the NSCL/P group (29.3%). DDEs in the anterior teeth were significantly associated with cleft laterality, being most frequent in bilateral clefts (p < 0.01).

Conclusion

Children with NSCL/P have a higher prevalence of DDE than those without clefts. MIH was the most prevalent defect observed in this population, highlighting its clinical relevance.