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Purpose <p>Planar cardiac scintigraphy with [<sup>123</sup>I]I-mIBG is widely used to image myocardial sympathetic activity. In multicentre studies, different γ-cameras can cause variability in quantitative parameters. This study aimed to harmonise multicentre [<sup>123</sup>I]I-mIBG data using a custom-designed phantom and to assess its feasibility and acceptability.</p> Methods <p>A ‘tube and bottle’ phantom was designed to standardise the heart-to-mediastinum (H/M) ratio across 15 centres. Each centre prepared three versions of the phantom (A, B, and C) with varying pertechnetate ([<sup>99m</sup>Tc]Tc-O4-) activities, acquired static images using their own γ-camera, and uploaded DICOM data to a shared platform. In the phantom, the tube and bottle represent the heart and mediastinum, respectively, with the tube-to-bottle (T/B) ratio simulating the H/M ratio. The reference centre analysed the images and calculated the T/B ratios, applying linear regression for data harmonisation. A survey was conducted to assess the phantom’s usability.</p> Results <p>The harmonised T/B ratios for versions A and B were 20.46 ± 0.78 and 6.19 ± 0.39, respectively. The average slope and intercept of the regression line across the participating centres resulted in 1.07 ± 0.38 and − 0.82 ± 4.95. Survey feedback indicated high feasibility and acceptability, with all centres recommending the phantom for multicentre harmonisation.</p> Conclusions <p>The custom-made phantom effectively harmonised experimental data across different centres, supporting its use in multicentre studies to improve data consistency.</p>

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Multi-centre data harmonisation applied to heart-to-mediastinum quantification in parkinsonism (ITA-MIBG): a cross-calibration phantom study with tube and bottle

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月3日

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  • Luca Filippi,
  • Francesco Bianconi,
  • Matteo Minestrini,
  • Giuseppe De Vincentis,
  • Viviana Frantellizzi,
  • Andrea Marongiu,
  • Cristina Ferrari,
  • Alessia Giordano,
  • Daniela D’Ambrosio,
  • Maria Gazzilli,
  • Francesco Bertagna,
  • Oreste Bagni,
  • Stefano Panareo,
  • Priscilla Guglielmo,
  • Achille Lazzarato,
  • Massimiliano Casali,
  • Gayane Aghakhanyan,
  • Angela Spanu,
  • Laura Evangelista,
  • Orazio Schillaci,
  • Barbara Palumbo

摘要

Purpose

Planar cardiac scintigraphy with [123I]I-mIBG is widely used to image myocardial sympathetic activity. In multicentre studies, different γ-cameras can cause variability in quantitative parameters. This study aimed to harmonise multicentre [123I]I-mIBG data using a custom-designed phantom and to assess its feasibility and acceptability.

Methods

A ‘tube and bottle’ phantom was designed to standardise the heart-to-mediastinum (H/M) ratio across 15 centres. Each centre prepared three versions of the phantom (A, B, and C) with varying pertechnetate ([99mTc]Tc-O4-) activities, acquired static images using their own γ-camera, and uploaded DICOM data to a shared platform. In the phantom, the tube and bottle represent the heart and mediastinum, respectively, with the tube-to-bottle (T/B) ratio simulating the H/M ratio. The reference centre analysed the images and calculated the T/B ratios, applying linear regression for data harmonisation. A survey was conducted to assess the phantom’s usability.

Results

The harmonised T/B ratios for versions A and B were 20.46 ± 0.78 and 6.19 ± 0.39, respectively. The average slope and intercept of the regression line across the participating centres resulted in 1.07 ± 0.38 and − 0.82 ± 4.95. Survey feedback indicated high feasibility and acceptability, with all centres recommending the phantom for multicentre harmonisation.

Conclusions

The custom-made phantom effectively harmonised experimental data across different centres, supporting its use in multicentre studies to improve data consistency.