In this paper, we prove the existence and uniqueness of the solution f(z, t) of the Loewner PDE with normalization \(Df(0,t)=e^{tA}\) , where \(A\in L(X,X)\) is such that \(k_+(A)<2m(A)\) , on the unit ball of a separable reflexive complex Banach space X. In particular, we obtain the biholomorphicity of the univalent Schwarz mappings v(z, s, t) with normalization \(Dv(0,s,t)=e^{-(t-s)A}\) for \(t\ge s\ge 0\) , where \(m(A)>0\) , which satisfy the semigroup property on the unit ball of a complex Banach space X. We further obtain the biholomorphicity of A-normalized univalent subordination chains under some normality condition on the unit ball of a reflexive complex Banach space X. We prove the existence of the biholomorphic solutions f(z, t) of the Loewner PDE with normalization \(Df(0,t)=e^{tA}\) on the unit ball of a separable reflexive complex Banach space X. The results obtained in this paper give some positive answers to the open problems and conjectures proposed by the authors in 2013.