In this article, we construct two classes of mixed-alphabet quasi-cyclic codes over finite rings. The first is a family of \(\mathbb {Z}_2\mathbb {Z}_4\) -additive quasi-cyclic codes of index \((l_1, l_2)\) and block length \((l_1m,\, l_2m)\) , where m is an odd positive integer. The second is a family of \(\mathbb {Z}_4\) -double quasi-cyclic codes of index \((l_1, l_2)\) and block length \((l_1m_1,\, l_2m_2)\) , where \(m_1, m_2,\) and 4 are pairwise coprime positive integers. We study their algebraic structures and determine the generator matrices for codes in these classes. Using a probabilistic approach, we establish their asymptotic properties. For any positive real number \(\delta < \frac{l_1 + l_2}{2(l_1 + 2l_2)}\) , and 2-ary entropy \(h_2\!\left( \frac{(l_1 + 2l_2)\delta }{l_1 + l_2}\right) < \frac{1}{2}\) , the rate of random \(\mathbb {Z}_2\mathbb {Z}_4\) -additive quasi-cyclic codes converges to \(\frac{1}{l_1 + 2l_2}\) . Similarly, for any positive real number \(\delta < 1\) , and 4-ary entropy \(h_4\!\left( \frac{\delta (l_1m_1 + l_2m_2)}{2(l_1 + l_2)}\right) < \frac{1}{4}\) , the rate of random \(\mathbb {Z}_4\) -double quasi-cyclic codes converges to \(\frac{1}{l_1m_1 + l_2m_2}\) . In both cases, the relative minimum distance converges to at least \(\delta \) . Therefore, both classes of codes are asymptotically good.