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<p>In order to advance in the fight against plasmid-mediated resistance, it is necessary to deepen our understanding of the role played by these DNA molecules. In this sense, the achievements obtained from experimentation validated by mathematical models have contributed to the discovery of key properties in the dynamics of antibiotic resistance. In this work, we attempt to characterize some of these properties through nonlinear functional responses of both plasmid replication and plasmid transfer. The results of the mathematical modeling performed here suggest that the emergence of antibiotic resistance in an individual due to the transfer of plasmid-borne resistance genes is directly associated with the production capacity of both recipient and donor bacteria. Whereas for persistence, in addition to bacterial replication, specific properties associated with plasmid replication and transfer are required.</p>

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On qualitative properties of replication and transfer of conjugative plasmids encoding antibiotic resistance genes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月7日

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  • Eduardo Ibarguen-Mondragón,
  • Lourdes Esteva,
  • M. Victoria Otero-Espinar,
  • Edgar Vega,
  • Miller Cerón-Gómez

摘要

In order to advance in the fight against plasmid-mediated resistance, it is necessary to deepen our understanding of the role played by these DNA molecules. In this sense, the achievements obtained from experimentation validated by mathematical models have contributed to the discovery of key properties in the dynamics of antibiotic resistance. In this work, we attempt to characterize some of these properties through nonlinear functional responses of both plasmid replication and plasmid transfer. The results of the mathematical modeling performed here suggest that the emergence of antibiotic resistance in an individual due to the transfer of plasmid-borne resistance genes is directly associated with the production capacity of both recipient and donor bacteria. Whereas for persistence, in addition to bacterial replication, specific properties associated with plasmid replication and transfer are required.