In this paper, we are concerned with the Fučik spectrum of fractional Schrödinger operators \({\varvec{(-\Delta )^{s}+V}}\) , which is defined as the set \({\varvec{\Sigma _{K}}}\) of all \({\varvec{(\alpha , \beta ) \in \mathbb {R}^{2}}}\) such that \(\begin{aligned} {\varvec{(-\Delta )^{s} u+V(x) u=\alpha u^{+}-\beta u^{-}, \quad x \in \mathbb {R}^{N}}} \end{aligned}\) has a non-trivial solution \({\varvec{u}}\) , where \({\varvec{u^{\pm }=\max \{\pm u, 0\}}}\) , \({\varvec{N>2s}}\) , \({\varvec{s \in (0,1)}}\) and V is an external unbounded potential function. Based on variational method, it turns out that the Fučik spectrum has a first non-trivial curve \({\varvec{\mathcal {C}}}\) being Lipschitz continuous, decreasing and with a certain asymptotic behavior. And then, as applications, we obtain the existence of non-trivial solutions for nonlinear Schrödinger equations with non-resonant nonlinearity.