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Introduction <p>Hypertension-mediated organ damage (HMOD) is well established in the heart, kidneys, and vasculature; however, early markers of cerebral involvement remain poorly defined.</p> Aim <p>This multicenter, cross-sectional Brazilian study investigated impaired intracranial compliance (ICC) across hypertension (HT) stages in adults without neurological disease or antihypertensive therapy, aiming to characterize early cerebral hemodynamic changes potentially related to hypertension-mediated brain organ damage.</p> Methods <p>ICC was assessed noninvasively from intracranial pressure (ICP) waveforms using the P2/P1 ratio and time-to-peak (TTP).</p> Results <p>A total of 252 participants were included (52.4% men, 87.7% &lt; 65 years). Mean P2/P1 and TTP values were 1.32 and 0.25, respectively. Significant differences were found between prehypertension and stage 2 HT (<i>p</i> &lt; 0.001) and between stage 1 and 2 (<i>p</i> &lt; 0.05) for P2/P1, as well as between prehypertension and stage 2 for TTP (<i>p</i> &lt; 0.05). The Jonckheere–Terpstra test confirmed a progressive increase in both parameters across HT stages. Women presented higher values of P2/P1 and TTP in all stages.</p> Conclusions <p>These findings suggest early and progressive impairment of ICC with increasing blood pressure, supporting its potential relevance as an early marker of cerebrovascular dysfunction, especially in women.</p> Graphical Abstract <p></p>

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Impaired Intracranial Compliance: A New Hypertension-Mediated Brain Organ Damage?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Mikaelle C. Correia,
  • Sayuri Inuzuka,
  • Matheus Martins da Costa,
  • Ana Luiza Lima Sousa,
  • Priscila Valverde de Oliveira Vitorino,
  • Gustavo Frigieri,
  • Polyana Vulcano de Toledo Piza,
  • Audes Diógenes de Magalhães Feitosa,
  • Rodrigo Bezerra,
  • Mayara Cedrim Santos,
  • Marco Antônio Mota-Gomes,
  • Andréa Araujo Brandão,
  • Erika Maria Gonçalves Campana,
  • Eduardo Costa Duarte Barbosa,
  • Christian da Silva Dal Pont,
  • Antonio Coca,
  • Weimar K. S. Barroso

摘要

Introduction

Hypertension-mediated organ damage (HMOD) is well established in the heart, kidneys, and vasculature; however, early markers of cerebral involvement remain poorly defined.

Aim

This multicenter, cross-sectional Brazilian study investigated impaired intracranial compliance (ICC) across hypertension (HT) stages in adults without neurological disease or antihypertensive therapy, aiming to characterize early cerebral hemodynamic changes potentially related to hypertension-mediated brain organ damage.

Methods

ICC was assessed noninvasively from intracranial pressure (ICP) waveforms using the P2/P1 ratio and time-to-peak (TTP).

Results

A total of 252 participants were included (52.4% men, 87.7% < 65 years). Mean P2/P1 and TTP values were 1.32 and 0.25, respectively. Significant differences were found between prehypertension and stage 2 HT (p < 0.001) and between stage 1 and 2 (p < 0.05) for P2/P1, as well as between prehypertension and stage 2 for TTP (p < 0.05). The Jonckheere–Terpstra test confirmed a progressive increase in both parameters across HT stages. Women presented higher values of P2/P1 and TTP in all stages.

Conclusions

These findings suggest early and progressive impairment of ICC with increasing blood pressure, supporting its potential relevance as an early marker of cerebrovascular dysfunction, especially in women.

Graphical Abstract