Scholarlink

Introduction <p>Hypertension is leading non communicable disease associated with high morbidity and mortality. There is uncertainty about the superiority of angiotensin receptor blocker (ARB)–diuretic versus ARB–calcium channel blocker (CCB) combination for the treatment of hypertension.</p> Aim <p>This meta-analysis compares the effectiveness of angiotensin receptor blocker (ARB)–diuretic versus ARB–calcium channel blocker (CCB) combination therapies in adults with hypertension.</p> Methods <p> RCTs were identified through PubMed, Embase, Scopus, and Cochrane Central; data were analyzed using RevMan 5.4.1 with a random-effects model. Primary outcomes were mortality, systolic blood pressure (SBP), and diastolic blood pressure (DBP); secondary outcomes included serum electrolytes and renal function.</p> Results <p> 3549 studies were identified based on database searches. 19 studies were included for analyses. Meta-analysis revealed no significant difference between both the combination therapies for primary outcomes: all-cause mortality [RR: 1.19 (95% CI: 0.85 to 1.65; <i>p</i> = 0.31)], SBP [MD: 1.24 mmHg (95% CI: − 0.48 to 2.96; <i>p</i> = 0.16; I² = 59%)], and DBP [MD: 0.62 mmHg (95% CI: − 0.15 to 1.38; <i>p</i> = 0.11; I² = 0%)]. The diuretic group showed significant changes in serum sodium, chloride, creatinine, e-GFR, and increased uric acid. Risk of bias was mostly low, with moderate to high evidence certainty.</p> Conclusion <p> Both ARB + CCB and ARB + diuretic combinations showed comparable effectiveness in lowering blood pressure and all-cause mortality in hypertensive adults. ARB + CCB seems to be having good safety profile, with better renal functions based on biomarkers.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Efficacy and Safety of ARB-Based Combination Therapies for Treatment of Hypertension: A Systematic Review and Meta-analyses

  • 期刊论文

  • 发表日期：

    2026年1月16日

查看全文
  • Ranu Oza,
  • Pravesh Aggarwal,
  • Pankaj Bhardwaj,
  • Rimple Jeet Kaur,
  • Deepak Kumar,
  • Akhil Dhanesh Goel,
  • Dharamveer Yadav,
  • Manoj Gupta,
  • Nitin Joshi,
  • Chandra Prabha,
  • Jaykaran Charan

摘要

Introduction

Hypertension is leading non communicable disease associated with high morbidity and mortality. There is uncertainty about the superiority of angiotensin receptor blocker (ARB)–diuretic versus ARB–calcium channel blocker (CCB) combination for the treatment of hypertension.

Aim

This meta-analysis compares the effectiveness of angiotensin receptor blocker (ARB)–diuretic versus ARB–calcium channel blocker (CCB) combination therapies in adults with hypertension.

Methods

RCTs were identified through PubMed, Embase, Scopus, and Cochrane Central; data were analyzed using RevMan 5.4.1 with a random-effects model. Primary outcomes were mortality, systolic blood pressure (SBP), and diastolic blood pressure (DBP); secondary outcomes included serum electrolytes and renal function.

Results

3549 studies were identified based on database searches. 19 studies were included for analyses. Meta-analysis revealed no significant difference between both the combination therapies for primary outcomes: all-cause mortality [RR: 1.19 (95% CI: 0.85 to 1.65; p = 0.31)], SBP [MD: 1.24 mmHg (95% CI: − 0.48 to 2.96; p = 0.16; I² = 59%)], and DBP [MD: 0.62 mmHg (95% CI: − 0.15 to 1.38; p = 0.11; I² = 0%)]. The diuretic group showed significant changes in serum sodium, chloride, creatinine, e-GFR, and increased uric acid. Risk of bias was mostly low, with moderate to high evidence certainty.

Conclusion

Both ARB + CCB and ARB + diuretic combinations showed comparable effectiveness in lowering blood pressure and all-cause mortality in hypertensive adults. ARB + CCB seems to be having good safety profile, with better renal functions based on biomarkers.