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Introduction <p>Routine assessment of abdominal aorta (AA) is not currently advised by the available guidelines, although hypertension is a major risk factor for the development of AA aneurysm.</p> Aim <p>In the present study, we assessed correlations and predictive factors of AA dimension in a cohort of hypertensive patients.</p> Methods <p>3083 Patients ≥ 18 years old with available AA ultrasound were included. AA dilatation was defined as an AA diameter ≥ 25 mm. Correlations of AA dimension and dilatation with demographics and metabolic profile were explored. Multivariable regression was also used to identify potential confounders influencing univariate correlations. To evaluate the prognostic impact of AA dilatation a propensity score model was implemented, and survival probability curves were constructed using the Kaplan-Meier method.</p> Results <p>Increased AA diameter was independently associated with older age, male sex, active smoking, higher diastolic and lower systolic blood pressure, higher LV mass index and aortic root dimension and less use of β-blockers at baseline (all <i>p </i>&lt; 0.05). A significant effect of baseline use of β-blockers and calcium channel blockers therapy were found (all <i>p</i> &lt; 0.01). During a mean follow-up of 4.76 ± 2.91 years, 32 MACE occurred. Kaplan-Meier analysis showed that having AA ≥ 25 mm is associated with significant risk of MACE compared to patients with AA &lt; 25 mm.</p> Conclusions <p>AA remodeling is strongly influenced by the cardiovascular (CV) risk profile and hypertension mediated target organ damage and AA dilatation contributes to increased CV risk in treated hypertensive patients.</p> Graphical Abstract <p></p>

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Abdominal Aorta Remodeling in Hypertensive Patients: The Campania Salute Network

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月13日

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  • Costantino Mancusi,
  • Ilaria Fucile,
  • Daniela Pacella,
  • Christian Basile,
  • Maria Virginia Manzi,
  • Maria Lembo,
  • Grazia Canciello,
  • Carmine De Luca,
  • Maddalena Tesone,
  • Stefano Cristiano,
  • Giuseppe Giugliano,
  • Maria Angela Losi,
  • Nicola De Luca,
  • Eduardo Bossone,
  • Raffaele Piccolo,
  • Carmine Morisco,
  • Raffaele Izzo,
  • Giovanni Esposito

摘要

Introduction

Routine assessment of abdominal aorta (AA) is not currently advised by the available guidelines, although hypertension is a major risk factor for the development of AA aneurysm.

Aim

In the present study, we assessed correlations and predictive factors of AA dimension in a cohort of hypertensive patients.

Methods

3083 Patients ≥ 18 years old with available AA ultrasound were included. AA dilatation was defined as an AA diameter ≥ 25 mm. Correlations of AA dimension and dilatation with demographics and metabolic profile were explored. Multivariable regression was also used to identify potential confounders influencing univariate correlations. To evaluate the prognostic impact of AA dilatation a propensity score model was implemented, and survival probability curves were constructed using the Kaplan-Meier method.

Results

Increased AA diameter was independently associated with older age, male sex, active smoking, higher diastolic and lower systolic blood pressure, higher LV mass index and aortic root dimension and less use of β-blockers at baseline (all p < 0.05). A significant effect of baseline use of β-blockers and calcium channel blockers therapy were found (all p < 0.01). During a mean follow-up of 4.76 ± 2.91 years, 32 MACE occurred. Kaplan-Meier analysis showed that having AA ≥ 25 mm is associated with significant risk of MACE compared to patients with AA < 25 mm.

Conclusions

AA remodeling is strongly influenced by the cardiovascular (CV) risk profile and hypertension mediated target organ damage and AA dilatation contributes to increased CV risk in treated hypertensive patients.

Graphical Abstract