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Introduction <p>Lipoprotein(a) [Lp(a)] has been linked to myocardial fibrosis and endothelial dysfunction, proposed mechanisms for diastolic dysfunction (DD). This study assessed the association between elevated Lp(a) (≥ 50 mg/dL) and DD in patients with preserved ejection fraction (EF).</p> Aim <p>We analyzed 1492 adults (median age59) with an Lp(a) measurement and echocardiogram (1997–2024).</p> Methods <p>Diastolicdysfunction required ≥ 3 abnormal echo parameters, as per recent guidelines. Logisticregression adjusting for potential confounders was performed.</p> Results <p>Seventy-sevenpatients (5.1%) had DD. Lp(a) ≥ 50 mg/dL was not associated with DD [adjusted oddsratio (aOR): 0.89, 95% confidence interval (CI): 0.49–1.54]. However, age (aOR:1.03, p = 0.026), hypertension (aOR: 1.83, p = 0.042), diabetes mellitus (aOR: 2.43, p =0.002), and cardiovascular (CV) diseases (aOR: 1.90, p = 0.043) were associated withDD, while statin therapy was associated with reduced risk (aOR: 0.51, p = 0.016).</p> Conclusions <p>In the setting of preserved EF, Lp(a) was not associated with DD,emphasizing management of traditional CV risks.</p> Graphical Abstract <p></p>

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Association Between Elevated Lipoprotein(a) and Diastolic Dysfunction: A Retrospective Cohort Study

  • 期刊论文

  • 发表日期：

    2025年7月15日

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  • Hesham Sheashaa,
  • Kamal Awad,
  • Arshad Mohammed,
  • Juan M. Farina,
  • Mohammed Tiseer Abbas,
  • Milagros Pereyra Pietri,
  • Isabel G. Scalia,
  • Nima Baba Ali,
  • Nadera N. Bismee,
  • Sogol Attaripour Esfahani,
  • Omar Ibrahim,
  • Fatmaelzahraa Abdelfattah,
  • Ahmed K. Mahmoud,
  • Steven J. Lester,
  • David Simper,
  • Chadi Ayoub,
  • Reza Arsanjani

摘要

Introduction

Lipoprotein(a) [Lp(a)] has been linked to myocardial fibrosis and endothelial dysfunction, proposed mechanisms for diastolic dysfunction (DD). This study assessed the association between elevated Lp(a) (≥ 50 mg/dL) and DD in patients with preserved ejection fraction (EF).

Aim

We analyzed 1492 adults (median age59) with an Lp(a) measurement and echocardiogram (1997–2024).

Methods

Diastolicdysfunction required ≥ 3 abnormal echo parameters, as per recent guidelines. Logisticregression adjusting for potential confounders was performed.

Results

Seventy-sevenpatients (5.1%) had DD. Lp(a) ≥ 50 mg/dL was not associated with DD [adjusted oddsratio (aOR): 0.89, 95% confidence interval (CI): 0.49–1.54]. However, age (aOR:1.03, p = 0.026), hypertension (aOR: 1.83, p = 0.042), diabetes mellitus (aOR: 2.43, p =0.002), and cardiovascular (CV) diseases (aOR: 1.90, p = 0.043) were associated withDD, while statin therapy was associated with reduced risk (aOR: 0.51, p = 0.016).

Conclusions

In the setting of preserved EF, Lp(a) was not associated with DD,emphasizing management of traditional CV risks.

Graphical Abstract