<p>Soccer referees play a crucial role in maintaining the laws and spirit of the game. Since the early 2000s, research has focused on understanding and enhancing their performance. However, research on mental fatigue in soccer referees remains in its early stages. This Current Opinion article aims to critically summarize current knowledge of this phenomenon in soccer referees and highlight areas requiring future research. It explores how cognitive and physical demands during matches contribute to mental fatigue development, its potential impact on refereeing performance, and how pre-match, half-time, and post-match interventions might help alleviate or aid recovery from this phenomenon. Although only a small number of studies have investigated mental fatigue in soccer referees, evidence suggests that the combination of intense and prolonged cognitive and physical demands makes both field and assistant referees susceptible to mental fatigue during matches. This phenomenon may negatively impact multiple performance components, particularly decision-making accuracy. Although interventions such as brain endurance training, mindfulness practices, structured routines, recovery strategies, and sleep optimization could help mitigate mental fatigue, the application of these modalities in and around match play remains unexplored in refereeing populations, representing a critical research gap.</p>