Scholarlink

Background <p>Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can be identified by measuring tricuspid regurgitant jet velocity (TRJV). We looked for the possible efficacy of <span>l</span>-arginine for children with SCD who have elevated TRJV.</p> Methods <p>In total, 50 children with SCD who had TRJV higher than 2.5 m/s were randomly divided into two groups, each with 25 patients: group 1 (control group) and group 2 (treatment group). Group 2 received <span>l</span>-arginine at a dose of 0.1–0.2&#xa0;g/kg/day for 3 months. Transthoracic echocardiography was conducted to measure TRJV at baseline and after 3 months, and blood samples were collected at baseline and after 3 months to assess serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), nitric oxide (NO), <span>l</span>-arginine (LA), asymmetric dimethylarginine (ADMA), and LA/ADMA ratio.</p> Results <p>After 3 months of treatment, the <span>l</span>-arginine-treated group had significantly lower TRJV levels than the control group, and compared with baseline. They also had significantly lower NT-proBNP and significantly higher NO, LA and LA/ADMA ratios than the control group and compared with baseline. No significant differences in side effects were observed between the two groups, indicating that <span>l</span>-arginine is safe for these patients.</p> Conclusions <p><span>l</span>-arginine is associated with a reduction in TRJV, NT-proBNP, and improvements in NO biomarkers, suggesting it may be beneficial for reducing the risk of pulmonary hypertension in children with sickle cell disease.</p> Clinical Trial Registration <p>ClinicalTrials.gov identifier NCT05470998.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical Study to Evaluate the Possible Efficacy and Safety of l-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月17日

查看全文
  • Dalia A. Gomaa,
  • Sahar M. El‑Haggar,
  • Mohamed R. El-Shanshory,
  • Osama El-Razaky,
  • Dalia R. El‑Afify

摘要

Background

Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can be identified by measuring tricuspid regurgitant jet velocity (TRJV). We looked for the possible efficacy of l-arginine for children with SCD who have elevated TRJV.

Methods

In total, 50 children with SCD who had TRJV higher than 2.5 m/s were randomly divided into two groups, each with 25 patients: group 1 (control group) and group 2 (treatment group). Group 2 received l-arginine at a dose of 0.1–0.2 g/kg/day for 3 months. Transthoracic echocardiography was conducted to measure TRJV at baseline and after 3 months, and blood samples were collected at baseline and after 3 months to assess serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), nitric oxide (NO), l-arginine (LA), asymmetric dimethylarginine (ADMA), and LA/ADMA ratio.

Results

After 3 months of treatment, the l-arginine-treated group had significantly lower TRJV levels than the control group, and compared with baseline. They also had significantly lower NT-proBNP and significantly higher NO, LA and LA/ADMA ratios than the control group and compared with baseline. No significant differences in side effects were observed between the two groups, indicating that l-arginine is safe for these patients.

Conclusions

l-arginine is associated with a reduction in TRJV, NT-proBNP, and improvements in NO biomarkers, suggesting it may be beneficial for reducing the risk of pulmonary hypertension in children with sickle cell disease.

Clinical Trial Registration

ClinicalTrials.gov identifier NCT05470998.