Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation

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2024年2月28日

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Sara Rogers,
Patrick J. Silva,
George Udeani,
Monica Deleon,
Sriarchala Mutyala,
Ladan Panahi,
Asim Abu-Baker,
Gabriel Neal,
Kenneth S. Ramos

摘要

Background

Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs.

Case

Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy.

Conclusion

SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters.

Video abstract

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