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<p>There is a need for novel treatments for melanoma, for which current treatments targeting mutagenicity and immunogenicity are often limited by secondary resistance and severe adverse events. Individualised therapies utilising neoantigens (mutated proteins specific to an individual’s tumour) are being explored to leverage the patient’s own immune system to target cancer cells. Current trials include those exploring the combination of neoantigen vaccines with immune checkpoint inhibitors.</p>

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Neoantigen melanoma therapy has the potential to advance melanoma therapy and improve patient outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月8日

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  • Esther S. Kim,
  • Simon Fung

摘要

There is a need for novel treatments for melanoma, for which current treatments targeting mutagenicity and immunogenicity are often limited by secondary resistance and severe adverse events. Individualised therapies utilising neoantigens (mutated proteins specific to an individual’s tumour) are being explored to leverage the patient’s own immune system to target cancer cells. Current trials include those exploring the combination of neoantigen vaccines with immune checkpoint inhibitors.