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<p>Dronabinol and nabilone, synthetic cannabinoids (SCs) that mimic the psychoactive component of cannabis delta-9-tetrahydrocannabinol (THC), are approved in the USA for other indications, but not for chronic pain. The efficacy of THC SCs for chronic neuropathic pain is generally not supported by large well-designed studies, but there have been encouraging results from smaller studies in some chronic pain conditions. The harms of SCs for non-cancer chronic pain likely outweigh the benefits in young adults, adolescents, and patients with serious mental health, substance use disorder or those at risk of falls.</p>

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Keep an eye on trials of synthetic cannabinoids in chronic pain, although current evidence for their efficacy is lacking

  • 期刊论文

  • 发表日期：

    2025年10月11日

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  • Caroline Fenton,
  • Simon Fung

摘要

Dronabinol and nabilone, synthetic cannabinoids (SCs) that mimic the psychoactive component of cannabis delta-9-tetrahydrocannabinol (THC), are approved in the USA for other indications, but not for chronic pain. The efficacy of THC SCs for chronic neuropathic pain is generally not supported by large well-designed studies, but there have been encouraging results from smaller studies in some chronic pain conditions. The harms of SCs for non-cancer chronic pain likely outweigh the benefits in young adults, adolescents, and patients with serious mental health, substance use disorder or those at risk of falls.