Background <p>Prescribers’ knowledge significantly influences their prescribing decisions. Despite the abundance of drug information resources, mobilization of this knowledge at the point of care is slow and often incomplete. This highlights the importance of gaining deeper insights into prescribers’ lived experiences, including their needs, challenges, expectations, and decision-making contexts, to inform the development of pragmatic solutions.</p> Objective <p>The aim was to describe prescribers’ experiences of seeking and using drug information for patient care.</p> Methods <p>Bibliographic databases—Ovid MEDLINE, Ovid EMBASE, and Web of Science—were searched from their inception until December 2023 to retrieve English language publications. Titles and abstracts screening was followed by reading the relevant full texts of the retrieved citations. Themes and sub-themes related to prescribers’ experiences in accessing drug information were identified. Paragraphs and sentences from the selected papers were coded using NVivo. A thematic synthesis uncovered common threads and divergent perspectives across the articles.</p> Results <p>The review of 13 studies revealed that prescribers routinely seek drug information for patient consultations, with drug dosage, adverse drug reactions, and drug interactions identified as common priorities. However, they face significant challenges, such as difficulties in accessing information resources, keeping up-to-date, finding time for searching during consultations, and gaining skills in literature search and critical appraisal. Additionally, generalizing research findings to individual patients proved challenging, which limits the utility of the found information.</p> Conclusion <p>These findings underscore the need to support prescribers in overcoming these challenges. Knowledge products designed with these contextual insights in mind may enhance the accessibility and utility of drug information and ultimately improve patient safety.</p>