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<p>Anhedonia is the reduced ability to feel enjoyment or pleasure. It affects about 70% of patients with major depressive disorder and 52% of patients with bipolar depression and is a common residual symptom following treatment for depression. Despite being linked to poorer clinical outcomes, no treatments are approved for anhedonia. Standard antidepressant medications are used to help alleviate anhedonia symptoms and these may be used in combination with psychotherapy and brain stimulation therapies. The anti-anhedonic properties of ketamine have also been investigated in patients with treatment-resistant depression. Further research is required to identify treatments for this area of unmet need.</p>

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Addressing anhedonia in depression with antidepressant therapies

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Nicole L. France

摘要

Anhedonia is the reduced ability to feel enjoyment or pleasure. It affects about 70% of patients with major depressive disorder and 52% of patients with bipolar depression and is a common residual symptom following treatment for depression. Despite being linked to poorer clinical outcomes, no treatments are approved for anhedonia. Standard antidepressant medications are used to help alleviate anhedonia symptoms and these may be used in combination with psychotherapy and brain stimulation therapies. The anti-anhedonic properties of ketamine have also been investigated in patients with treatment-resistant depression. Further research is required to identify treatments for this area of unmet need.