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<p>Rheumatoid arthritis (RA) development begins with the preclinical phase that can progress to clinical RA. It is hypothesised that the prevention of RA in at-risk individuals may be possible with interventions targeting the preclinical phase. Predictors of RA development include the presence of autoantibodies, specific clinical features and subclinical inflammation on imaging. While methotrexate and abatacept have shown promising signals such as disease modulation and improvements in symptom burden, dexamethasone, atorvastatin and hydroxychloroquine have not demonstrated any preventive effects in RA development. Further studies with long-term follow-up are needed to ascertain a true effect of preventive therapies in RA.</p>

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Prevention of rheumatoid arthritis is challenging, but early intervention in at-risk individuals shows promise

  • 期刊论文

  • 发表日期：

    2025年5月11日

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  • Amy Zhuang-Yan

摘要

Rheumatoid arthritis (RA) development begins with the preclinical phase that can progress to clinical RA. It is hypothesised that the prevention of RA in at-risk individuals may be possible with interventions targeting the preclinical phase. Predictors of RA development include the presence of autoantibodies, specific clinical features and subclinical inflammation on imaging. While methotrexate and abatacept have shown promising signals such as disease modulation and improvements in symptom burden, dexamethasone, atorvastatin and hydroxychloroquine have not demonstrated any preventive effects in RA development. Further studies with long-term follow-up are needed to ascertain a true effect of preventive therapies in RA.