Scholarlink

Background <p>Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management but are associated with nephrotoxicity, particularly in senior populations. While the acute nephrotoxicity of NSAIDs is well established, evidence on their long-term effects on renal function—particularly in community-dwelling older adults—has been mixed across studies.</p> Objectives <p>This study investigated the association between NSAID use and chronic kidney disease (CKD) risk in the general senior population.</p> Methods <p>Data from the National Health Insurance Service-Senior Cohort (NHIS-SC) in South Korea were analyzed, including 1812 participants (604 NSAID users and 1208 controls) matched 1:2 by propensity score. Kidney dysfunction was defined as glomerular filtration rate (eGFR) &lt; 60 mL/min/1.73m<sup>2</sup> with a ≥ 10% decline from baseline. Hazard ratios (HRs) for CKD were estimated using Cox regression.</p> Results <p>NSAID use was associated with an increased CKD risk (HR 1.46; 95% confidence interval (CI) 1.11–1.93) and faster eGFR decline. Subgroup analysis showed elevated risks for Cox-1 (HR 1.53) and Cox-2 inhibitors (HR 1.61). End-stage renal disease (ESRD) incidence was rare and not significant.</p> Conclusions <p>NSAIDs increase CKD risk and accelerate kidney function decline in senior individuals. Cautious prescription and regular kidney monitoring are recommended, and further randomized trials are needed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of NSAIDs on Early CKD Development: A 10-Year Population-Based Study Using the Korean Senior Cohort

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月6日

查看全文
  • Jung-sun Lim,
  • Sujeong Han,
  • Jong Seung Kim,
  • Sunyoung Kim,
  • Bumjo Oh

摘要

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management but are associated with nephrotoxicity, particularly in senior populations. While the acute nephrotoxicity of NSAIDs is well established, evidence on their long-term effects on renal function—particularly in community-dwelling older adults—has been mixed across studies.

Objectives

This study investigated the association between NSAID use and chronic kidney disease (CKD) risk in the general senior population.

Methods

Data from the National Health Insurance Service-Senior Cohort (NHIS-SC) in South Korea were analyzed, including 1812 participants (604 NSAID users and 1208 controls) matched 1:2 by propensity score. Kidney dysfunction was defined as glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 with a ≥ 10% decline from baseline. Hazard ratios (HRs) for CKD were estimated using Cox regression.

Results

NSAID use was associated with an increased CKD risk (HR 1.46; 95% confidence interval (CI) 1.11–1.93) and faster eGFR decline. Subgroup analysis showed elevated risks for Cox-1 (HR 1.53) and Cox-2 inhibitors (HR 1.61). End-stage renal disease (ESRD) incidence was rare and not significant.

Conclusions

NSAIDs increase CKD risk and accelerate kidney function decline in senior individuals. Cautious prescription and regular kidney monitoring are recommended, and further randomized trials are needed.