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<p>Cerebral aspergillosis is a well-recognized and particularly severe manifestation of invasive aspergillosis, primarily affecting immunocompromised individuals. The condition is associated with high morbidity and mortality, largely due to diagnostic challenges and limited treatment options. This review examines the epidemiology, risk factors, and diagnostic issues before focusing on drug treatment, including the pharmacokinetics and pharmacodynamics of antifungal agents in the central nervous system. Resistance to current antifungal therapies is also discussed, along with future research directions.</p>

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Cerebral Aspergillosis: Diagnostic Challenges, Therapeutic Strategies, and Future Research

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月10日

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  • Louise Chantelot,
  • Emilie Sitterlé,
  • Sylvain Poirée,
  • Vincent Jullien,
  • François Danion,
  • Alexandra Serris

摘要

Cerebral aspergillosis is a well-recognized and particularly severe manifestation of invasive aspergillosis, primarily affecting immunocompromised individuals. The condition is associated with high morbidity and mortality, largely due to diagnostic challenges and limited treatment options. This review examines the epidemiology, risk factors, and diagnostic issues before focusing on drug treatment, including the pharmacokinetics and pharmacodynamics of antifungal agents in the central nervous system. Resistance to current antifungal therapies is also discussed, along with future research directions.