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Background and Objective <p>Symptomatic dermographism (SD), the most common chronic inducible urticaria subtype, manifests as strip-shaped, pruritic wheals after skin friction. Conclusive data on its associated factors are limited, and direct comparisons between individuals with and without SD remain scarce. We aimed to identify factors associated with SD internationally.</p> Methods <p>The PREVALENCE-D (Prevalence Estimation of Dermographism) study was an international cross-sectional survey conducted from 2021 to 2024 across 19 countries. An expert-designed questionnaire diagnosed SD and assessed potential associated factors. SD participants were defined as those who self-reported chronic recurrent urticarial dermographism with itch. Factors associated with SD were identified by comparing participants with and without SD.</p> Results <p>Of 68,513 participants, 3101 had SD (female 73.3%). Their mean age was 40.2 ± 16.2 years. Key factors associated with SD included atopic dermatitis (adjusted odds ratio [aOR] 4.20, 95% confidence interval [CI] 3.62‒4.88) and allergic rhinitis (aOR 2.11, 95% CI 1.88‒2.37). Participants with at least one atopic condition (allergic rhinitis, atopic dermatitis, or asthma) were significantly more likely to have SD (aOR 2.70, 95% CI 2.47‒2.95). Those with all three atopic conditions had a further increased likelihood of SD (aOR 7.75, 95% CI 5.31‒11.29). Other associations included working and older age groups, female sex, dyslipidemia, and thyroid disease.</p> Conclusions <p>Atopic dermatitis and allergic rhinitis emerged as the strongest correlates of SD, especially those with all three atopic conditions. Thus, allergic comorbidities should be assessed in SD patients. Further research is needed to clarify the pathophysiological relationship between these conditions and SD. [Graphical abstract available online]</p> Graphical Abstract <p></p>

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Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月17日

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  • Kanokvalai Kulthanan,
  • Jonathan A. Bernstein,
  • Michael Rudenko,
  • Pascale Salameh,
  • Chulaluk Komoltri,
  • Zainab Abdul Hameed,
  • Esra Adışen,
  • Salma Al Abri,
  • Mona Al-Ahmad,
  • Bushra Al Hinai,
  • Anastasiia Allenova,
  • Saad Alshareef,
  • Nattha Angkoolpakdeekul,
  • Rand Arnaout,
  • Joanna Bartosińska,
  • Ivan Cherrez-Ojeda,
  • Leena Chularojanamontri,
  • Paulo Ricardo Criado,
  • Heyam Elsaeed,
  • Roberta Fachini Jardim Criado,
  • Ahmed Farahat,
  • Cesar Alberto Galvan Calle,
  • Ana Maria Giménez-Arnau,
  • Kiran Godse,
  • Maia Gotua,
  • Mehmet Gülengül,
  • Michihiro Hide,
  • Naoko Inomata,
  • Chang-Gyu Jung,
  • Alicja Kasperska-Zając,
  • Maryam Khoshkhui,
  • Pavel Kolkhir,
  • Dorota Krasowska,
  • Jomgriditip Laomoleethorn,
  • Antonina Maiorowa,
  • Prynn Manuskiatti,
  • Raisa Meshkova,
  • Dragan Mijakoski,
  • Melba Muñoz,
  • Iman Nasr,
  • Denise Neiva Santos de Aquino Arnoldi,
  • Rabia Öztaş Kara,
  • Teerapat Paringkarn,
  • Juliette Pérez-Manich,
  • Indrashis Podder,
  • Karla Robles-Velasco,
  • Isabel Rosmaninho,
  • Phuwakorn Saengthong-aram,
  • Giorgi Shengelidze,
  • Sariya Sittiwanaruk,
  • Rana Tafrishi,
  • Natasa Teovska Mitrevska,
  • Vesna Trajkova,
  • Papapit Tuchinda,
  • Noldtawat Viriyaskultorn,
  • Teerapat Wannawittayapa,
  • Pornjira Wattanasillawat,
  • Anushka Wilson,
  • Young-Min Ye,
  • Anna Zalewska-Janowska,
  • Marcus Maurer,
  • Torsten Zuberbier

摘要

Background and Objective

Symptomatic dermographism (SD), the most common chronic inducible urticaria subtype, manifests as strip-shaped, pruritic wheals after skin friction. Conclusive data on its associated factors are limited, and direct comparisons between individuals with and without SD remain scarce. We aimed to identify factors associated with SD internationally.

Methods

The PREVALENCE-D (Prevalence Estimation of Dermographism) study was an international cross-sectional survey conducted from 2021 to 2024 across 19 countries. An expert-designed questionnaire diagnosed SD and assessed potential associated factors. SD participants were defined as those who self-reported chronic recurrent urticarial dermographism with itch. Factors associated with SD were identified by comparing participants with and without SD.

Results

Of 68,513 participants, 3101 had SD (female 73.3%). Their mean age was 40.2 ± 16.2 years. Key factors associated with SD included atopic dermatitis (adjusted odds ratio [aOR] 4.20, 95% confidence interval [CI] 3.62‒4.88) and allergic rhinitis (aOR 2.11, 95% CI 1.88‒2.37). Participants with at least one atopic condition (allergic rhinitis, atopic dermatitis, or asthma) were significantly more likely to have SD (aOR 2.70, 95% CI 2.47‒2.95). Those with all three atopic conditions had a further increased likelihood of SD (aOR 7.75, 95% CI 5.31‒11.29). Other associations included working and older age groups, female sex, dyslipidemia, and thyroid disease.

Conclusions

Atopic dermatitis and allergic rhinitis emerged as the strongest correlates of SD, especially those with all three atopic conditions. Thus, allergic comorbidities should be assessed in SD patients. Further research is needed to clarify the pathophysiological relationship between these conditions and SD. [Graphical abstract available online]

Graphical Abstract