Multi-functional Hollow Structures for Intelligent Drug Delivery

Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties, such as high loading capacities and programmed drug release. In particular, hollow multishell structures (HoMSs) with multilevel shell and space can regulate the molecular-level interaction between drugs and materials, so as to achieve the temporal-spatial order and sequential release of drugs. The anisotropic hollow structures can control the drug diffusion process by inducing the macroscopic interface flow through autonomous movement, realizing the targeted drug transport and release. In this paper, a key focus will be HoMSs with their temporal-ordered architectures and anisotropic hollow carriers with directional movement. Their synthesis mechanisms, structure-property relationships, smartly programmed drug delivery and biomedical applications will be discussed, providing insights into designing next-generation intelligent drug carriers.