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<p>Korsakoff syndrome (KS) presents an interdisciplinary challenge in diagnosis and care. The frequent lack of distinct clinical symptoms represents a&#xa0;diagnostic challenge and can complicate early diagnosis. This case report describes a&#xa0;59-year-old patient who initially presented to internal medicine due to symptoms that appeared to be associated with pre-known cardiovascular and metabolic comorbidities. The initial suspected diagnosis of osmotic demyelination syndrome (formerly known as pontine myelinolysis), which can induce a&#xa0;clinical state very similar to KS, could only be ruled out by MRI evidence of atrophy of the mammillary bodies, confirming the diagnosis of KS. High-dose thiamine supplementation, neurorehabilitative measures, and support by a&#xa0;stable social environment, led to an improvement in cognitive performance. This case highlights the need for differential diagnostic efforts regarding KS and interdisciplinary awareness beyond neurological and psychiatric disciplines.</p>

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Diagnostische Herausforderungen des Korsakow-Syndroms: Ein Fallbericht

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月16日

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  • Paula Hoppstock,
  • Lea Sommer,
  • Mathias Jachs,
  • Clemens Dejaco,
  • Gregor Kasprian,
  • Radheshyam Stepponat,
  • Armin Trojer,
  • Sabine Weber,
  • Stephan Listabarth,
  • Daniel König

摘要

Korsakoff syndrome (KS) presents an interdisciplinary challenge in diagnosis and care. The frequent lack of distinct clinical symptoms represents a diagnostic challenge and can complicate early diagnosis. This case report describes a 59-year-old patient who initially presented to internal medicine due to symptoms that appeared to be associated with pre-known cardiovascular and metabolic comorbidities. The initial suspected diagnosis of osmotic demyelination syndrome (formerly known as pontine myelinolysis), which can induce a clinical state very similar to KS, could only be ruled out by MRI evidence of atrophy of the mammillary bodies, confirming the diagnosis of KS. High-dose thiamine supplementation, neurorehabilitative measures, and support by a stable social environment, led to an improvement in cognitive performance. This case highlights the need for differential diagnostic efforts regarding KS and interdisciplinary awareness beyond neurological and psychiatric disciplines.