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<p>Breast cancer is prevalent among women and is characterized by mutations in breast cells leading to uncontrolled proliferation and tumour formation. Alterations in p53 function, including mutations or loss of expression, compromise its regulatory role in the cell cycle, resulting in unchecked cell division and tumour growth. Dysregulations of the Cyclin-dependent Kinases (CDKs), particularly CDK1, CDK2, CDK4, and CDK6, can exacerbate this process leading to a shift from senescence to enhanced proliferation. Targeting these CDKs within the p53 signalling pathway presents a promising anti-cancer strategy to induce apoptosis in BC cells. This study predicts the interaction of therapeutic druggable molecules from Indian and Chinese origins against CDKs using molecular docking. A publicly available database and literature were used to identify and select these CDKs. In silico tools facilitated the docking of these CDKs with Indian and Chinese molecules exhibiting favourable drug-like and pharmacokinetic properties, identifying promising compounds. Top docked complexes, such as CDK1-Michelalbine (Indian) and CDK1-Emodin (Chinese), alongside CDK1-Doxorubicin (conventional), were subjected to Molecular Dynamic Simulation for comparative analysis. Further analyses were conducted on significant CDKs to understand their expression, overall survival, and genetic alterations. This comprehensive in-silico approach uncovers potential novel therapeutic options for targeting CDKs in breast cancer.</p>

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Unlocking nature’s cure: utilizing Indian and Chinese medicinal plants as CDK inhibitors in the p53 pathway of breast cancer

  • 期刊论文

  • 发表日期：

    2026年3月27日

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  • Anudarshini Sathish Kumar,
  • Sohini Chakraborty,
  • Satarupa Banerjee

摘要

Breast cancer is prevalent among women and is characterized by mutations in breast cells leading to uncontrolled proliferation and tumour formation. Alterations in p53 function, including mutations or loss of expression, compromise its regulatory role in the cell cycle, resulting in unchecked cell division and tumour growth. Dysregulations of the Cyclin-dependent Kinases (CDKs), particularly CDK1, CDK2, CDK4, and CDK6, can exacerbate this process leading to a shift from senescence to enhanced proliferation. Targeting these CDKs within the p53 signalling pathway presents a promising anti-cancer strategy to induce apoptosis in BC cells. This study predicts the interaction of therapeutic druggable molecules from Indian and Chinese origins against CDKs using molecular docking. A publicly available database and literature were used to identify and select these CDKs. In silico tools facilitated the docking of these CDKs with Indian and Chinese molecules exhibiting favourable drug-like and pharmacokinetic properties, identifying promising compounds. Top docked complexes, such as CDK1-Michelalbine (Indian) and CDK1-Emodin (Chinese), alongside CDK1-Doxorubicin (conventional), were subjected to Molecular Dynamic Simulation for comparative analysis. Further analyses were conducted on significant CDKs to understand their expression, overall survival, and genetic alterations. This comprehensive in-silico approach uncovers potential novel therapeutic options for targeting CDKs in breast cancer.