Purpose <p>Few studies have examined nutrient-specific antioxidant intake and health-related quality of life (HRQoL) in Middle Eastern populations. This cross-sectional study was conducted to investigate the association between dietary antioxidant intakes and HRQoL among Iranian adults.</p> Methods <p>Using data from the Tehran Lipid and Glucose Study, we included 1,766 adults (54.3% female) with a mean age of 39.4 ± 13.2 years. Dietary intake of antioxidant vitamins and minerals—including vitamin A, vitamin C, vitamin E, zinc (Zn), magnesium (Mg), selenium (Se), manganese (Mn), and β-carotene—was assessed using a Food Frequency Questionnaire. HRQoL was evaluated using a validated questionnaire. General linear models were used to assess the associations between individual antioxidant nutrients and HRQoL scores.</p> Results <p>In women, higher vitamin A intake was significantly associated with greater HRQoL and its dimensions, except for “role physical,” “bodily pain,” and “vitality.” Increased vitamin C intake was associated with better “physical function,” “role physical,” and the physical component summary (PCS) in women (<i>P</i> = 0.043, 0.035, and 0.047, respectively). Mg intake showed a direct association with “physical function” (<i>P</i> = 0.045), “general health” (<i>P</i> = 0.012), “mental health” (<i>P</i> = 0.001), and the mental component summary (MCS) (<i>P</i> = 0.027) in men. In women, however, the associations were primarily related to physical aspects, specifically “physical function” (<i>P</i> = 0.017), “role physical” (<i>P</i> = 0.003), and the PCS (<i>P</i> = 0.008). Higher Se intake was correlated with improved PCS in both sexes, with women also showing notable improvements in “role physical” (<i>P</i> = 0.002) and “bodily pain” (<i>P</i> = 0.004).</p> Conclusions <p>The study highlights that increased consumption of vitamins A and C, Mg, and Se is associated wtih better HRQoL, especially in women, with significant improvements in physical HRQoL.</p>