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Background <p>Bone strength is influenced by the stiffness and spatial distribution of mineralized tissue. Bone mineral density (BMD) is used to assess osteoporosis but is limited in evaluating microarchitectural and geometric changes. We investigated Trabecular Bone Score (TBS), BMD, and hip structural analysis (HSA) in celiac disease (CD) patients.</p> Methods <p>A cross-sectional study compared bone density factors in CD patients with a healthy control group matched for gender, BMI, and age. Dual-energy X-ray absorptiometry (DXA) assessed BMD at the femoral neck, hip, and lumbar spine (L1-L4). TBS was measured at the lumbar spine, and HSA evaluated geometry at the narrow neck (NN), femoral shaft (FS), and intertrochanteric (IT) regions.</p> Results <p>The study included 73 CD patients and 93 healthy controls. The prevalence of low BMD for age at the lumbar spine, total hip, femoral neck, and at any skeletal site was significantly higher in the CD group compared with controls (<i>P</i> &lt; 0.05). No significant differences were found in TBS between groups (<i>P</i> &gt; 0.05). IT buckling ratio (BR), FS BR, and FS endocortical diameter were significantly higher in the CD group, while IT cortical thickness, FS cross-sectional area, and FS cortical thickness were significantly higher in controls (<i>P</i> &lt; 0.05).</p> Conclusion <p>Patients with celiac disease demonstrated adverse DXA-derived structural and densitometric skeletal parameters, which may potentially contribute to increased skeletal fragility, highlighting the importance of assessing both BMD and structural factors.</p>

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Hip geometry, trabecular bone score, and bone mineral density in patients with celiac disease: a multi-center cross-sectional study in Southern Iran

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Arzhang Naseri,
  • Alireza Keshtkar,
  • Ramina Mofarrah,
  • Amirreza Sabahizadeh,
  • Mostafa Farhadi,
  • Ehsan Shojaeefard,
  • Farnaz Atighi,
  • Pedram Talezadeh,
  • Seyed Taghi Heydari,
  • Marzieh Bakhshayeshkaram,
  • Mohammad Mahdi Dabbaghmanesh,
  • Ramin Niknam,
  • Mohammad Reza Fattahi,
  • Ebrahim Fallahzadeh,
  • Mohammad Hossein Dabbaghmanesh

摘要

Background

Bone strength is influenced by the stiffness and spatial distribution of mineralized tissue. Bone mineral density (BMD) is used to assess osteoporosis but is limited in evaluating microarchitectural and geometric changes. We investigated Trabecular Bone Score (TBS), BMD, and hip structural analysis (HSA) in celiac disease (CD) patients.

Methods

A cross-sectional study compared bone density factors in CD patients with a healthy control group matched for gender, BMI, and age. Dual-energy X-ray absorptiometry (DXA) assessed BMD at the femoral neck, hip, and lumbar spine (L1-L4). TBS was measured at the lumbar spine, and HSA evaluated geometry at the narrow neck (NN), femoral shaft (FS), and intertrochanteric (IT) regions.

Results

The study included 73 CD patients and 93 healthy controls. The prevalence of low BMD for age at the lumbar spine, total hip, femoral neck, and at any skeletal site was significantly higher in the CD group compared with controls (P < 0.05). No significant differences were found in TBS between groups (P > 0.05). IT buckling ratio (BR), FS BR, and FS endocortical diameter were significantly higher in the CD group, while IT cortical thickness, FS cross-sectional area, and FS cortical thickness were significantly higher in controls (P < 0.05).

Conclusion

Patients with celiac disease demonstrated adverse DXA-derived structural and densitometric skeletal parameters, which may potentially contribute to increased skeletal fragility, highlighting the importance of assessing both BMD and structural factors.