Purpose <p>Psychosocial stress may explain metabolic health disparities observed among immigrants, including Arab Americans (AA). This study examined the psychosocial stressors, including parent-adolescent relationships, discrimination, and acculturative stress, and how they affect the risk for metabolic syndrome among AA adolescents and their parents.</p> Methods <p>Using a cross-sectional descriptive and community-based design, we recruited 80 AA parent-adolescent dyads (<i>N</i> = 160) from Southeast Michigan. Parents and adolescents completed a survey about their parent-adolescent relationships, experiences with discrimination, and acculturative stress. Anthropometric measures and blood samples were taken at home visits. Analysis includes Wilcoxon signed-rank, Spearman’s rank, and actor–partner interdependence models (APIM).</p> Results <p>26% (<i>n</i> = 20) of parents and 10% (<i>n</i> = 8) of adolescents met metabolic syndrome criteria. A one-unit increase in parent-reported conflict with adolescents was associated with 15% higher odds of adolescents’ metabolic syndrome, and each unit increase in parent-reported involvement was associated with 9% lower odds of adolescents’ metabolic syndrome. However, neither association was significant (Wald χ²(1) = 3.54, <i>p</i> = .060 and Wald χ²(1) = 2.75, <i>p</i> = .097, respectively). Adolescents-reported acculturative stress was positively associated with their number of metabolic syndrome symptoms, but not significant (Wald χ²(1) = 2.74, <i>p</i> = .098). In contrast, the effect of parental-reported acculturative stress on adolescent number of symptoms was positive and significant (Wald χ²(1) = 6.20, <i>p</i> = .013).</p> Conclusion <p>Psychosocial stressors (e.g., acculturative stress) have a substantial impact on AA adolescents’ cardiovascular and metabolic health. Parent-adolescent relationships may function as a risk or protective mechanism.</p>