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Background <p>This study aimed to resolve conflicting findings on the association between polymorphisms in the glutathione S-transferase (GST) genes and gestational diabetes mellitus (GDM) by conducting a meta-analysis.</p> Methods <p>A meta-analysis of case-control studies was conducted in accordance with the PRISMA 2020 guidelines. Comprehensive literature searches were performed in PubMed, Web of Science, and Google Scholar (title search only) up to January 31, 2025. Genotypic distribution between pregnant women with and without GDM was collated. Data were independently extracted by two reviewers into a standardized spreadsheet, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model.</p> Results <p>The meta-analysis included 1,933 pregnant women (932 with GDM and 1,001 controls). Of the three <i>GST</i> polymorphisms analyzed (<i>GSTM1</i>, <i>GSTT1</i>, and <i>GSTP1</i>), only the <i>GSTM1</i> deletion polymorphism was significantly associated with GDM with moderate heterogeneity.</p> Conclusion <p>This meta-analysis supports a significant association between the <i>GSTM1</i> deletion polymorphism and the development of GDM. Further studies are needed to validate this association and elucidate underlying mechanisms.</p>

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Association of the glutathione s-transferase polymorphisms with gestational diabetes mellitus: a meta-analysis of Asian populations

  • 期刊论文

  • 发表日期：

    2025年12月4日

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  • Raphael Enrique Tiongco,
  • Imoan Shallom Calma,
  • Chastene Christopher Gozum,
  • Maria Angelica Manao,
  • Francess Leighn Ayson,
  • Pia Vanessa Basilio,
  • Angela Khristine Malig,
  • Sunshine Miranda,
  • Eliezer John Castro,
  • Michael John Dominguez

摘要

Background

This study aimed to resolve conflicting findings on the association between polymorphisms in the glutathione S-transferase (GST) genes and gestational diabetes mellitus (GDM) by conducting a meta-analysis.

Methods

A meta-analysis of case-control studies was conducted in accordance with the PRISMA 2020 guidelines. Comprehensive literature searches were performed in PubMed, Web of Science, and Google Scholar (title search only) up to January 31, 2025. Genotypic distribution between pregnant women with and without GDM was collated. Data were independently extracted by two reviewers into a standardized spreadsheet, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model.

Results

The meta-analysis included 1,933 pregnant women (932 with GDM and 1,001 controls). Of the three GST polymorphisms analyzed (GSTM1, GSTT1, and GSTP1), only the GSTM1 deletion polymorphism was significantly associated with GDM with moderate heterogeneity.

Conclusion

This meta-analysis supports a significant association between the GSTM1 deletion polymorphism and the development of GDM. Further studies are needed to validate this association and elucidate underlying mechanisms.