Scholarlink

Background <p>To the best of our knowledge, the effect of Pistacia atlantica seed oil on liver enzymes and renal factors in humans is unknown. This study aimed to compare the effects of a blend of Pistacia atlantica seed-canola oil, corn-canola oil with tertiary butylhydroquinone (TBHQ), and corn-canola oil without TBHQ on these markers in patients with metabolic syndrome (MetS).</p> Methods <p>This randomized, triple-blind, three-way crossover clinical trial (RCT) involved participants replacing their usual dietary oil with the intervention oils. Serum aspartate transferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Gamma-glutamyl transpeptidase (GGT), Blood urea nitrogen (BUN), Creatinine (Cr), and estimated glomerular filtration rate (eGFR) were measured at baseline and end of each intervention period.</p> Results <p>A total of 66 adults aged 40.08 ± 6.12 completed the study. We found no significant difference between serum levels of liver and kidney function tests following intervention oils intake after adjustment for all potential confounders (Mean change in serum AST (IU/ ml): -0.25,-4.62,-0.22; ALT (IU/ ml): -0.36,-2.51,2.25; ALP (IU/ ml): -11.03,-9.22,-6.98; GGT (IU/ ml):0.63,-1.06,2.42; BUN (mg/dl): -0.16,-0.16,-1.94; Creatinine (mg/dl):0.02,0.06,0.01; eGFR (mL/min/1.73&#xa0;m²): -1.54,-4.54,-0.69, for corn-canola oil with TBHQ, and corn-canola oil without TBHQ, and a blend of Pistacia atlantica seed-canola oil, respectively. <i>P</i> &lt; 0.05).</p> Conclusions <p>The replacement of habitual dietary oils with either Pistacia atlantica seed-canola oil or corn-canola oils with and without TBHQ might not affect liver enzymes and renal function markers in adults with MetS. Future clinical trials with longer follow-up periods are needed to confirm these findings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative effects of pistacia Atlantica seed-canola oil and corn-canola oils with and without TBHQ on liver and kidney function tests in patients with metabolic syndrome: A triple-blind crossover clinical trial

  • 期刊论文

  • 发表日期：

    2025年11月20日

查看全文
  • Faezeh Zademohammadi,
  • Bahareh Sasanfar,
  • Fateme Sadeghi Nodoushan,
  • Bita Forootani,
  • Arezoo sadat Emrani,
  • Amirhossein Najafi,
  • Sara Jambarsang,
  • Sayyed Saeed Khayatzadeh,
  • Fatemeh Pourrajab,
  • Akram Ghadiri-Anari,
  • Amin Salehi-Abargouei

摘要

Background

To the best of our knowledge, the effect of Pistacia atlantica seed oil on liver enzymes and renal factors in humans is unknown. This study aimed to compare the effects of a blend of Pistacia atlantica seed-canola oil, corn-canola oil with tertiary butylhydroquinone (TBHQ), and corn-canola oil without TBHQ on these markers in patients with metabolic syndrome (MetS).

Methods

This randomized, triple-blind, three-way crossover clinical trial (RCT) involved participants replacing their usual dietary oil with the intervention oils. Serum aspartate transferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Gamma-glutamyl transpeptidase (GGT), Blood urea nitrogen (BUN), Creatinine (Cr), and estimated glomerular filtration rate (eGFR) were measured at baseline and end of each intervention period.

Results

A total of 66 adults aged 40.08 ± 6.12 completed the study. We found no significant difference between serum levels of liver and kidney function tests following intervention oils intake after adjustment for all potential confounders (Mean change in serum AST (IU/ ml): -0.25,-4.62,-0.22; ALT (IU/ ml): -0.36,-2.51,2.25; ALP (IU/ ml): -11.03,-9.22,-6.98; GGT (IU/ ml):0.63,-1.06,2.42; BUN (mg/dl): -0.16,-0.16,-1.94; Creatinine (mg/dl):0.02,0.06,0.01; eGFR (mL/min/1.73 m²): -1.54,-4.54,-0.69, for corn-canola oil with TBHQ, and corn-canola oil without TBHQ, and a blend of Pistacia atlantica seed-canola oil, respectively. P < 0.05).

Conclusions

The replacement of habitual dietary oils with either Pistacia atlantica seed-canola oil or corn-canola oils with and without TBHQ might not affect liver enzymes and renal function markers in adults with MetS. Future clinical trials with longer follow-up periods are needed to confirm these findings.