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Objectives <p>Type 2 diabetes is a complex disease characterized by progressive β-cell failure. The primary mechanism underlying this failure is the progressive loss of pancreatic β-cell function. The aim of this study is to identify the key gene expression changes in human pancreatic isolated islets of patients with type 2 diabetes.</p> Methods <p>We extracted gene expression data in human pancreatic isolated islets of patients with type 2 diabetes and healthy controls from Gene Expression Omnibus (GEO) and analyzed it using GEO2R program. We then assessed the significant differentially expressed genes (DEGs) using protein-protein interaction (PPI) network analysis. The critical genes were enriched via gene ontology and discussed.</p> Results <p>Among the 93 significant DEGs, five critical genes including ITGB2, APOE, BIRC5, GABRA2, and IL1B were emerged as key players in type 2 diabetes. Notably, “Alzheimer disease, type 4” was identified as a major class of biological terms altered in type 2 diabetes.</p> Conclusions <p>Our findings suggest that the introduced critical genes are potential targets for controlling type 2 diabetes. Furthermore, the crucial role of APOE as a link between type 2 diabetes and Alzheimer’s disease or other cognitive disorders was confirmed.</p>

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Highlighted gene expression alteration in human pancreatic isolated islets in patients with type 2 diabetes

  • 期刊论文

  • 发表日期：

    2025年4月23日

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  • Vahid Mansouri,
  • Babak Arjmand,
  • Mohammad Rostami Nejad,
  • Zahra Razzaghi,
  • Mostafa Rezaei-Tavirani,
  • Farideh Razi,
  • Fatemeh Bandarian,
  • Reza M. Robati,
  • Mitra Rezaei,
  • Fatemeh Daneshimehr

摘要

Objectives

Type 2 diabetes is a complex disease characterized by progressive β-cell failure. The primary mechanism underlying this failure is the progressive loss of pancreatic β-cell function. The aim of this study is to identify the key gene expression changes in human pancreatic isolated islets of patients with type 2 diabetes.

Methods

We extracted gene expression data in human pancreatic isolated islets of patients with type 2 diabetes and healthy controls from Gene Expression Omnibus (GEO) and analyzed it using GEO2R program. We then assessed the significant differentially expressed genes (DEGs) using protein-protein interaction (PPI) network analysis. The critical genes were enriched via gene ontology and discussed.

Results

Among the 93 significant DEGs, five critical genes including ITGB2, APOE, BIRC5, GABRA2, and IL1B were emerged as key players in type 2 diabetes. Notably, “Alzheimer disease, type 4” was identified as a major class of biological terms altered in type 2 diabetes.

Conclusions

Our findings suggest that the introduced critical genes are potential targets for controlling type 2 diabetes. Furthermore, the crucial role of APOE as a link between type 2 diabetes and Alzheimer’s disease or other cognitive disorders was confirmed.