The impact of osteosarcopenia and its parameters on mortality of COVID-19 in-hospitalized older patients: the findings of BEH (Bushehr elderly health) program

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发表日期：

2024年6月12日

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Gita Shafiee,
Maryam Marzban,
Faeze Abbaspour,
Amirhossein Darabi,
Narges Zargar Balajam,
Akram Farhadi,
Mohammad Mehdi Khaleghi,
Hossein Taherzadeh,
Noushin Fahimfar,
Azar Falahatzadeh,
Negin Ghasemi,
Afshin Ostovar,
Iraj Nabipour,
Bagher Larijani,
Ramin Heshmat

摘要

Background

It has been documented that old age and chronic diseases are associated with poor prognosis and mortality among COVID-19 patients. Osteosarcopenia is a geriatric syndrome with a considerable prevalence which increases morbidity and mortality. This study investigated the relationship between COVID-19 mortality and osteosarcopenia and its parameters in-hospitalized patients in Bushehr, Iran.

Methods

In this retrospective cohort study, participants of the Bushehr Elderly Health (BEH) program who were hospitalized due to COVID-19 between 1st March 2020 and 23rd September 2021 were assessed. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We used the Cox proportional hazards model to identify the association between oteosarcopenia and the risk of COVID-mortality in 2442 person-days.

Results

Among 4173 participants,297 patients were in-hospitalized due to COVID-19. We found that 80(26.94%) patients expired due to COVID-19 during the follow-up period. Osteosarcopenia and its parameters were more prevalent in patients who expired. The incidence rate of mortality among osteosarcopenic patients was 5.04(3.43– 7.40) per 100 person-days. In the Cox proportional hazards models, osteosarcopenia and its parameters increase the risk of COVID-mortality [Osteosarcopenia: HR_adjusment:1.73(1.00-3.01), sarcopenia: HR_adjusment:1.72(1.00-2.99), Osteoporosis: HR_adjusment:2.67(1.53–4.67), Low muscle mass: HR_adjusment:1.90(1.05–3.46), low muscle strength: HR_adjusment:1.80(1.03–3.16), and low gait speed: HRadj:2.39(1.31–4.38). The ORs of ICU admission and use of invasive mechanical ventilation among osteosarcopenic patients and its parameters were higher than those without it.

Conclusions

This study identified the impact of osteosarcopenia and its parameters on the mortality of in-hospitalized patients with COVID-19. Assessment of musculoskeletal disorders could help in early warning of older patients with severe COVID-19.