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<p>The latest evidence indicates that vault RNAs (vtRNAs) may be involved in the growth and advancement of cancer. In this case-control study, we used quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) to detect the expression of two vault RNAs (vtRNA1-1 and vtRNA1-2) in peripheral blood mononuclear cells (PBMCs) from 50 colorectal cancer (CRC) patients and 60 healthy individuals. The expression levels of vtRNA1-1 and vtRNA1-2 were significantly upregulated in colorectal cancer cases (<i>p</i> &lt; 0.05). In addition, correlation analysis revealed that vtRNA1-2 was significantly associated with TNM staging, while vtRNA1-1 showed a strong correlation with only tumor location. The receiver operating characteristic (ROC) curve analysis showed that it has a good predictive value for the risk of CRC. In conclusion, these findings suggest that vtRNA1-1 and vtRNA1-2 may be associated with CRC progression and could serve as potential biomarkers for disease detection. Further functional studies are required to determine their mechanistic roles in CRC biology.</p>

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Expression Patterns of vtRNA1-1 and vtRNA1-2 and their Association with Colorectal Cancer

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Nima Garman,
  • Zivar Salehi,
  • Farzam Ajamian,
  • Farhad Mashayekhi,
  • Hamid Saeidi Saedi

摘要

The latest evidence indicates that vault RNAs (vtRNAs) may be involved in the growth and advancement of cancer. In this case-control study, we used quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) to detect the expression of two vault RNAs (vtRNA1-1 and vtRNA1-2) in peripheral blood mononuclear cells (PBMCs) from 50 colorectal cancer (CRC) patients and 60 healthy individuals. The expression levels of vtRNA1-1 and vtRNA1-2 were significantly upregulated in colorectal cancer cases (p < 0.05). In addition, correlation analysis revealed that vtRNA1-2 was significantly associated with TNM staging, while vtRNA1-1 showed a strong correlation with only tumor location. The receiver operating characteristic (ROC) curve analysis showed that it has a good predictive value for the risk of CRC. In conclusion, these findings suggest that vtRNA1-1 and vtRNA1-2 may be associated with CRC progression and could serve as potential biomarkers for disease detection. Further functional studies are required to determine their mechanistic roles in CRC biology.