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<p>&#xa0;Cutaneous Leishmaniasis (CL) appears as a localized skin lesion that is curable without any clinical intervention. However, <i>Leishmania </i>infection rarely manifests as non-healing lesions, persisting for many years. The current study aimed to assess the sixth exon of <i>IL12RB1</i> in patients afflicted by the non-healing form of CL (NHCL).<i> Leishmania</i> infection was diagnosed through a direct smear. The sixth exon of the <i>IL12RB1</i> was sequenced with no polymorphisms detected in the sixth exon of the <i>IL12RB1</i> gene; therefore, suggesting that the sixth exon of <i>IL12RB1</i> was not contributing to the NHCL phenotype.</p>

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Evaluation of the Sixth Exon of IL12RB1 in Patients Afflicted by the Non-Healing Form of Cutaneous Leishmaniasis

  • 期刊论文

  • 发表日期：

    2025年10月16日

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  • Mohammad Moafi,
  • Hossien Rezvan,
  • Roya Taleban,
  • Marjan Mansourian,
  • Fatemeh Sokhanvari,
  • Nazli Ansari,
  • Roya Sherkat

摘要

 Cutaneous Leishmaniasis (CL) appears as a localized skin lesion that is curable without any clinical intervention. However, Leishmania infection rarely manifests as non-healing lesions, persisting for many years. The current study aimed to assess the sixth exon of IL12RB1 in patients afflicted by the non-healing form of CL (NHCL). Leishmania infection was diagnosed through a direct smear. The sixth exon of the IL12RB1 was sequenced with no polymorphisms detected in the sixth exon of the IL12RB1 gene; therefore, suggesting that the sixth exon of IL12RB1 was not contributing to the NHCL phenotype.