Purpose of Review <p>Social isolation and loneliness are prevalent among stroke survivors and have negative consequences on physical and psychological well-being. This review aims to provide a comprehensive overview and evidence-based recommendations to assist clinicians and researchers in understanding the evaluation and treatment options to address social isolation and loneliness in individuals after stroke.</p> Recent Findings <p>This review outlines a framework for understanding social isolation, loneliness, and related concepts, followed by a discussion of the potential mechanisms involved. This review also summarizes various assessments for measuring these concepts and provides recommendations on treatment options for stroke survivors. However, the knowledge about post-stroke social isolation and loneliness is limited, necessitating careful use of appropriate measures and treatments in specific contexts.</p> Summary <p>Our review synthesizes the literature on managing social isolation and loneliness post-stroke. Future research should focus on developing specific strategies to enhance social connections among individuals after stroke.</p>