Purpose of Review <p>Pediatric Emergency Medicine (PEM) in high-resource settings continues to benefit from technological advancements, standardized protocols, and advanced training. However, PEM in low-resource settings—despite facing infrastructure limitations, funding gaps, and high disease burdens—offers innovative, adaptable, and culturally grounded care. This review explores how insights from low-resource pediatric emergency care can inform and enrich practices in high-resource settings.</p> Recent Findings <p>Emerging literature highlights the value of frugal innovations and culturally contextualized care in low-resource PEM. Examples such as bubble CPAP, task-shifting models, and mobile health (mHealth) interventions have demonstrated scalable, cost-effective impact. Collaborative programs like Rwanda’s Human Resources for Health (HRH) initiative and the Global Initiative for Children’s Surgery (GICS) emphasize sustainable capacity-building and bidirectional learning. High-resource institutions increasingly recognize the need for integrating global health training, emphasizing equity, ethical engagement, and adaptability in complex care environments.</p> Summary <p>Low-resource PEM settings foster clinical ingenuity, resilience, and a strong emphasis on local leadership. Integrating lessons from these contexts can enhance global equity, encourage innovation, and improve cultural competence among trainees. Global health must be framed as a core component of PEM training to bridge healthcare disparities and support sustainable, ethical partnerships across diverse settings</p>