Purpose of Review <p>This article aims to describe intercostal cryoablation’s impact on Minimally Invasive Repairs of Pectus Excavatum (MIRPE) or Nuss procedures and the management of postoperative pain.</p> Recent Findings <p>Cryoablation has emerged as a key component to multimodal postoperative pain management following MIRPE. Recent well-done studies have demonstrated that intraoperative cryoablation leads to shorter hospital lengths of stay and reduced opioid requirements during and after discharge without compromising pain control. Hospital length of stay has shortened from an average of 5&#xa0;days to 1&#xa0;day. Some centers have even reported successful same-day discharge following MIRPE. Additionally, cryoablation has markedly reduced time away from school and need for physical therapy.</p> Summary <p>Pectus excavatum is the most common chest wall deformity in pediatric patients. Postoperative pain control after MIRPE was a significant challenge due to the duration and intensity of pain associated with remodeling the anterior chest wall. Throughout the years, pain management after MIRPE has evolved. Various pain management strategies, such as thoracic epidurals, incisional pain pumps, paravertebral blocks, multimodal pain regimens and patient-controlled analgesics, have been employed to address the challenge of achieving adequate postoperative pain control. However, these pain strategies were typically short-acting relative to the duration of pain from MIRPE. The introduction of intercostal nerve cryoablation during MIRPE transformed the landscape of postoperative pain management by offering long-lasting, opioid-sparing analgesia. Compared to the traditional methods, cryoablation has been shown to reduce hospital length of stay and opioid consumption, both during and after hospitalization, without sacrificing pain control.</p>