Purpose of Review <p>This review explores strategies for managing and preventing complications associated with total parenteral nutrition (TPN), an essential therapy for patients who cannot meet their nutritional needs through oral or enteral routes. It addresses methods to reduce complications such as infections, thrombosis, and metabolic imbalances, as well as ways to improve the safety and effectiveness of TPN use in both short- and long-term settings.</p> Recent Findings <p>Recent studies highlight the importance of aseptic techniques and proper catheter selection in reducing catheter-related infections and thrombosis. The use of both antibiotic and non-antibiotic lock therapies has been effective in preventing infections. Furthermore, advancements in anticoagulation protocols and customized nutrition plans are vital for improving patient care. Careful monitoring for complications such as hyperglycemia, electrolyte imbalances, and liver dysfunction is essential, especially for patients requiring long-term total parenteral nutrition (TPN).</p> Summary <p>The review concludes that complications associated with TPN can be reduced through multidisciplinary care and adherence to evidence-based practices. Effective strategies include proper management of catheters, individualized nutrition plans, and meticulous monitoring for metabolic disturbances. Future research should focus on refining TPN formulations and improving prevention methods to enhance patient safety and the quality of care.</p>