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Purpose <p>To describe the physiological aging processes of the pancreas, such as increased fat deposition, fibrosis, volume reduction, and to understand these age-related changes with imaging (US, CT, MRI) from birth to senesence.</p> Recent Findings <p>Aging of the pancreas is a physiological process, but certain pathological conditions and lifestyle habits can accelerate this process. Morover, aging of the pancreas represents a factor of developing neoplastic changes with an increasing risk of pancreatic ductal adenocarcinoma (PDAC).</p> Summary <p>Imaging of the pancreas differs significantly between age groups due to physiological changes and the prevalence of certain conditions. In children, the pancreas is generally easier to image with ultrasound and appears homogeneous on CT and MRI. In adults and the elderly, the aging pancreas commonly shows normal structural changes like volume loss, increased fat deposition and fibrosis, visible on US, CT, and especially MRI, which offers better tissue characterization. While imaging reveals these findings, it’s crucial to distinguish these common age/lifestyle changes from pathology like chronic pancreatitis or malignancy precursors.</p>

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Imaging of Aging Pancreas

  • 期刊论文

  • 发表日期：

    2025年8月29日

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  • Luisa Tomaiuolo,
  • Luca Geraci,
  • Giovanni Morana

摘要

Purpose

To describe the physiological aging processes of the pancreas, such as increased fat deposition, fibrosis, volume reduction, and to understand these age-related changes with imaging (US, CT, MRI) from birth to senesence.

Recent Findings

Aging of the pancreas is a physiological process, but certain pathological conditions and lifestyle habits can accelerate this process. Morover, aging of the pancreas represents a factor of developing neoplastic changes with an increasing risk of pancreatic ductal adenocarcinoma (PDAC).

Summary

Imaging of the pancreas differs significantly between age groups due to physiological changes and the prevalence of certain conditions. In children, the pancreas is generally easier to image with ultrasound and appears homogeneous on CT and MRI. In adults and the elderly, the aging pancreas commonly shows normal structural changes like volume loss, increased fat deposition and fibrosis, visible on US, CT, and especially MRI, which offers better tissue characterization. While imaging reveals these findings, it’s crucial to distinguish these common age/lifestyle changes from pathology like chronic pancreatitis or malignancy precursors.