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<p>Purpose: Polycystic ovary syndrome (PCOS) is a common endocrine condition among women, associated with cardiometabolic comorbidities. This review explores the risk of metabolic disease in adolescents with PCOS and its association with disease phenotypes.Methods: We reviewed current literature on metabolic risk in adolescents with PCOS, including studies on insulin resistance, cardiovascular and adipose tissue dysfunction, and hepatic steatosis.Results: Evidence indicates that adolescents with PCOS have increased risk for insulin resistance, cardiovascular and adipose tissue dysfunction, and hepatic steatosis. These metabolic risks vary according to disease phenotypes and may persist into adulthood.Conclusion: Early diagnosis of PCOS and targeted lifestyle interventions are critical to mitigating cardiometabolic risk and improving long-term health outcomes.</p>

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Metabolic Implications of PCOS

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • Amna Naveed,
  • Rachana Shah,
  • Angelina Bernier,
  • Valeriia Muradova,
  • Eray Savgan Gurol,
  • Melanie Cree,
  • Rachel Whooten

摘要

Purpose: Polycystic ovary syndrome (PCOS) is a common endocrine condition among women, associated with cardiometabolic comorbidities. This review explores the risk of metabolic disease in adolescents with PCOS and its association with disease phenotypes.Methods: We reviewed current literature on metabolic risk in adolescents with PCOS, including studies on insulin resistance, cardiovascular and adipose tissue dysfunction, and hepatic steatosis.Results: Evidence indicates that adolescents with PCOS have increased risk for insulin resistance, cardiovascular and adipose tissue dysfunction, and hepatic steatosis. These metabolic risks vary according to disease phenotypes and may persist into adulthood.Conclusion: Early diagnosis of PCOS and targeted lifestyle interventions are critical to mitigating cardiometabolic risk and improving long-term health outcomes.