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Introduction <p>Despite refractive correction and patching, some patients have residual amblyopia. In the current study, we compared the effectiveness of daily 6-hours&#xa0;(6-h) intensive patching and a newly developed individualized and adaptive vision training (iAVT) protocol for residual amblyopia in children.</p> Methods <p>In a randomized clinical trial, 60 children aged 4 to under 11&#xa0;years with residual amblyopia and visual acuity ranging from 0.2 to 0.8 logarithm of the minimum angle of resolution (logMAR) were assigned to receive either 50 sessions of iAVT training or 6&#xa0;h of daily patching for 10&#xa0;weeks.</p> Results <p>Visual acuity in the amblyopic eye improved more in the iAVT group than in the extended patching group (0.13 versus 0.07 logMAR; 95% confidence interval (CI) 0.010–0.100; <i>p</i> = 0.017) over 10&#xa0;weeks. At 2&#xa0;weeks, the iAVT group also showed a faster improvement compared with the patching group (0.09 versus 0.06 logMAR; 95% CI −0.004 to 0.067; <i>p</i> = 0.076). Meanwhile, no significant between-group difference was found in the area under the log contrast sensitivity function (AULCSF) change. However, the AULCSF of the iAVT group showed a marginally significant within-group improvement from base to week 10 (0.78 versus 0.89; 95% CI −0.225 to 0.001; <i>p</i> = 0.056), while no significant change was observed in the patching group. The iAVT group also reported higher quality-of-life scores after treatment, as monitored by the Pediatric Eye Questionnaire.</p> Conclusions <p>The iAVT provided a faster and more effective treatment for residual amblyopia compared with 6-h patching within the 10-week treatment period. These results suggest that iAVT may be an important new approach to treating residual amblyopia.</p> Trail Registration <p>Chinese Clinical Trial Registry, ChiCTR2300075594. Registered on 8 September 2023—retrospectively registered.</p>

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Effect of Individualized and Adaptive Vision Training versus 6 hours of Patching in Children with Residual Amblyopia: A Randomized Clinical Trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月9日

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  • Junli Yuan,
  • Yuanyuan Chen,
  • Lu Wang,
  • Meiping Xu,
  • Na Liao,
  • Zhiyue Dai,
  • Hui Chen,
  • Binjun Zhang,
  • Jinling Xu,
  • Minghui Wan,
  • Suzhong Xu,
  • Yuwen Wang,
  • Xiaolin Huang,
  • Fuhao Zheng,
  • Pingping Huang,
  • Jie Chen,
  • Chang-Bing Huang,
  • Fang-Fang Yan,
  • Xinping Yu,
  • Huanyun Yu

摘要

Introduction

Despite refractive correction and patching, some patients have residual amblyopia. In the current study, we compared the effectiveness of daily 6-hours (6-h) intensive patching and a newly developed individualized and adaptive vision training (iAVT) protocol for residual amblyopia in children.

Methods

In a randomized clinical trial, 60 children aged 4 to under 11 years with residual amblyopia and visual acuity ranging from 0.2 to 0.8 logarithm of the minimum angle of resolution (logMAR) were assigned to receive either 50 sessions of iAVT training or 6 h of daily patching for 10 weeks.

Results

Visual acuity in the amblyopic eye improved more in the iAVT group than in the extended patching group (0.13 versus 0.07 logMAR; 95% confidence interval (CI) 0.010–0.100; p = 0.017) over 10 weeks. At 2 weeks, the iAVT group also showed a faster improvement compared with the patching group (0.09 versus 0.06 logMAR; 95% CI −0.004 to 0.067; p = 0.076). Meanwhile, no significant between-group difference was found in the area under the log contrast sensitivity function (AULCSF) change. However, the AULCSF of the iAVT group showed a marginally significant within-group improvement from base to week 10 (0.78 versus 0.89; 95% CI −0.225 to 0.001; p = 0.056), while no significant change was observed in the patching group. The iAVT group also reported higher quality-of-life scores after treatment, as monitored by the Pediatric Eye Questionnaire.

Conclusions

The iAVT provided a faster and more effective treatment for residual amblyopia compared with 6-h patching within the 10-week treatment period. These results suggest that iAVT may be an important new approach to treating residual amblyopia.

Trail Registration

Chinese Clinical Trial Registry, ChiCTR2300075594. Registered on 8 September 2023—retrospectively registered.