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Introduction <p>This study aimed to assess the in vivo positioning, tilt, and decentration of the second-generation implantable miniature telescope (SING-IMT™; Samsara Vision, Inc., Far Hills, NJ, USA) using swept-source anterior segment optical coherence tomography (AS-OCT).</p> Methods <p>This was a multicentric retrospective observational study conducted at two tertiary referral centers (Palagi Hospital, Florence, Italy, and Royal Victoria Infirmary Hospital, Newcastle upon Tyne, UK). Eleven eyes from 11 patients with end-stage age-related macular degeneration (AMD) underwent secondary SING IMT™ implantation at these two tertiary centers. Using high-resolution AS-OCT (CASIA2 system [Tomey, Nagoya, Japan] and Anterion system [Heidelberg Engineering, Heidelberg, Germany]), telescope alignment was assessed after 12&#xa0;months. Decentration and tilt were calculated and reported in both Cartesian and polar coordinates. Telescope configuration relative to the iris plane and corneal–telescope (C-T) distance and endothelial cell count was also evaluated.</p> Results <p>The mean (± standard deviation) follow-up was&#xa0;15.7 ± 2.8&#xa0;months<b>.</b> The mean decentration was 0.33 ± 0.12&#xa0;mm, with a predominant superior and nasal displacement. Mean tilt was 3.28 ± 1.31°, oriented mainly in the supero-temporal direction. Three positional configurations were observed: anterior to the iris plane (36.4%), at the iris plane (36.4%), and posterior to the iris plane (27.3%). The mean C–T distance was 2.71 ± 0.48&#xa0;mm. Mean endothelial cell loss at 12&#xa0;months was 13.21% ± 3.57%.</p> Conclusions <p>After 12&#xa0;months of follow-up, the SING IMT™ maintained stable in-the-bag fixation, with tilt and decentration values within the ranges previously reported for conventional in-the-bag intraocular lenses.</p>

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In Vivo Evaluation of SING IMT™ Alignment for Late-Stage Age-Related Macular Degeneration Using Anterior Segment OCT

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月12日

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  • Lorenzo de Angelis,
  • Mario Galasso,
  • Sandro Di Simplicio,
  • Raffaele Raimondi,
  • Faustino Vidal-Aroca,
  • Mario R. Romano,
  • Mario Damiano Toro,
  • Stanislao Rizzo,
  • Francesco Barca

摘要

Introduction

This study aimed to assess the in vivo positioning, tilt, and decentration of the second-generation implantable miniature telescope (SING-IMT™; Samsara Vision, Inc., Far Hills, NJ, USA) using swept-source anterior segment optical coherence tomography (AS-OCT).

Methods

This was a multicentric retrospective observational study conducted at two tertiary referral centers (Palagi Hospital, Florence, Italy, and Royal Victoria Infirmary Hospital, Newcastle upon Tyne, UK). Eleven eyes from 11 patients with end-stage age-related macular degeneration (AMD) underwent secondary SING IMT™ implantation at these two tertiary centers. Using high-resolution AS-OCT (CASIA2 system [Tomey, Nagoya, Japan] and Anterion system [Heidelberg Engineering, Heidelberg, Germany]), telescope alignment was assessed after 12 months. Decentration and tilt were calculated and reported in both Cartesian and polar coordinates. Telescope configuration relative to the iris plane and corneal–telescope (C-T) distance and endothelial cell count was also evaluated.

Results

The mean (± standard deviation) follow-up was 15.7 ± 2.8 months. The mean decentration was 0.33 ± 0.12 mm, with a predominant superior and nasal displacement. Mean tilt was 3.28 ± 1.31°, oriented mainly in the supero-temporal direction. Three positional configurations were observed: anterior to the iris plane (36.4%), at the iris plane (36.4%), and posterior to the iris plane (27.3%). The mean C–T distance was 2.71 ± 0.48 mm. Mean endothelial cell loss at 12 months was 13.21% ± 3.57%.

Conclusions

After 12 months of follow-up, the SING IMT™ maintained stable in-the-bag fixation, with tilt and decentration values within the ranges previously reported for conventional in-the-bag intraocular lenses.