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Introduction <p>We analyzed longitudinal epithelial changes after the treatment of myopia with keratorefractive lenticule extraction (KLEx) and the zonal change in epithelial thickness up to 12&#xa0;months after SmartSight for myopic astigmatism with the SCHWIND ATOS femtosecond laser.</p> Methods <p>We used anterior segment optical coherence tomography (AS-OCT) data and analyzed changes in the epithelium after treatment to ascertain how much epithelium hyperplasia occurred after KLEx. Data from 80 eyes treated with SmartSight, with a complete follow-up from postoperative day&#xa0;1 (POD1) to 12&#xa0;months postoperative, were used. The mean age of the patients was 29 ± 6&#xa0;years with a mean spherical equivalent (SEQ) of − 4.72 ± 1.97&#xa0;diopters (D) (− 1.25 to − 9.88&#xa0;D) and a mean magnitude of refractive astigmatism of 0.90 ± 0.89 D. Preoperative central epithelial thickness was from 46 to 67&#xa0;µm.</p> Results <p>Postoperative central epithelial thickness at 12-month follow-up was 3 ± 5&#xa0;µm thicker than preoperatively. The other epithelial zones (nasal, superior, temporal, inferior) thickened by + 4 ± 4&#xa0;µm. The epithelial change showed larger variability at POD1 and stabilized from 1&#xa0;week onwards. Postoperatively, the change in epithelium was not different for the different zones, and it did not correlate with the achieved refractive changes for any zone at any time point.</p> Conclusions <p>The changes in epithelial thickness after KLEx for moderate myopia with SmartSight were minimal, indicating a low level of epithelial hyperplasia without resembling a regression-inducing lentoid. Findings suggest that KLEx with SCHWIND ATOS has a subtle impact on the epithelial thickness (with postoperative epithelium becoming slightly thicker). However, the differences remain below any clinical relevance.</p>

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Epithelial Remodelling in Myopia After Keratorefractive Lenticule Extraction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月10日

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  • Maja Bohač,
  • Ivan Gabrić,
  • Sara Blazhevska,
  • Mateja Jagić,
  • Samuel Arba Mosquera

摘要

Introduction

We analyzed longitudinal epithelial changes after the treatment of myopia with keratorefractive lenticule extraction (KLEx) and the zonal change in epithelial thickness up to 12 months after SmartSight for myopic astigmatism with the SCHWIND ATOS femtosecond laser.

Methods

We used anterior segment optical coherence tomography (AS-OCT) data and analyzed changes in the epithelium after treatment to ascertain how much epithelium hyperplasia occurred after KLEx. Data from 80 eyes treated with SmartSight, with a complete follow-up from postoperative day 1 (POD1) to 12 months postoperative, were used. The mean age of the patients was 29 ± 6 years with a mean spherical equivalent (SEQ) of − 4.72 ± 1.97 diopters (D) (− 1.25 to − 9.88 D) and a mean magnitude of refractive astigmatism of 0.90 ± 0.89 D. Preoperative central epithelial thickness was from 46 to 67 µm.

Results

Postoperative central epithelial thickness at 12-month follow-up was 3 ± 5 µm thicker than preoperatively. The other epithelial zones (nasal, superior, temporal, inferior) thickened by + 4 ± 4 µm. The epithelial change showed larger variability at POD1 and stabilized from 1 week onwards. Postoperatively, the change in epithelium was not different for the different zones, and it did not correlate with the achieved refractive changes for any zone at any time point.

Conclusions

The changes in epithelial thickness after KLEx for moderate myopia with SmartSight were minimal, indicating a low level of epithelial hyperplasia without resembling a regression-inducing lentoid. Findings suggest that KLEx with SCHWIND ATOS has a subtle impact on the epithelial thickness (with postoperative epithelium becoming slightly thicker). However, the differences remain below any clinical relevance.