Scholarlink

Introduction <p>Serious bacterial infections among newborns are associated with significant morbidity, mortality, and economic costs. While most newborns fully recover following the acute phase of illness, some develop long-term complications that require medical care. The objective of this real-world study was to estimate acute and long-term healthcare utilization and expenditures among US newborns with bacterial meningitis or sepsis during their birth hospitalization.</p> Methods <p>A retrospective matched-cohort design and a US healthcare claims database were employed. Study population comprised newborns who, during their birth hospitalization, had evidence of meningitis or sepsis due to a bacterial pathogen and matched comparison newborns. Study measures included all-cause healthcare utilization and expenditures during the birth hospitalization as well as the 1-year period following discharge.</p> Results <p>Among newborns with bacterial meningitis (<i>N</i> = 678), 61% were born prematurely, 27% had low birthweight, and 56% had ≥ 1 high-risk condition; among those with bacterial sepsis (<i>N</i> = 33,478), corresponding values were 48%, 20%, and 33%. During the birth hospitalization, utilization and expenditures were higher (versus comparators) among newborns with meningitis (hospital days, 37 versus 23; intensive care unit [ICU], 97% versus 64%; expenditures, US $423,390 versus $168,861) and sepsis (hospital days, 18 versus 14; ICU, 93% versus 52%; expenditures, $139,973 versus $78,549). Mean levels during the 1-year follow-up period were also markedly higher (versus comparators) among newborns with meningitis (expenditures: by $218,464) or sepsis (expenditures: by $39,259).</p> Conclusions <p>Serious bacterial infections among newborns place a substantial burden on the US healthcare system for the treatment of acute illness as well as long-term complications. Interventions targeting the prevention of newborn bacterial infections have the potential to yield significant resource utilization and cost offsets.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月27日

查看全文
  • Kristen N. Noble,
  • Katharina Schley,
  • Lisa Abramovitz,
  • Sarah J. Willis,
  • Kyla Hayford,
  • Jennifer C. Moisi,
  • Derek Weycker

摘要

Introduction

Serious bacterial infections among newborns are associated with significant morbidity, mortality, and economic costs. While most newborns fully recover following the acute phase of illness, some develop long-term complications that require medical care. The objective of this real-world study was to estimate acute and long-term healthcare utilization and expenditures among US newborns with bacterial meningitis or sepsis during their birth hospitalization.

Methods

A retrospective matched-cohort design and a US healthcare claims database were employed. Study population comprised newborns who, during their birth hospitalization, had evidence of meningitis or sepsis due to a bacterial pathogen and matched comparison newborns. Study measures included all-cause healthcare utilization and expenditures during the birth hospitalization as well as the 1-year period following discharge.

Results

Among newborns with bacterial meningitis (N = 678), 61% were born prematurely, 27% had low birthweight, and 56% had ≥ 1 high-risk condition; among those with bacterial sepsis (N = 33,478), corresponding values were 48%, 20%, and 33%. During the birth hospitalization, utilization and expenditures were higher (versus comparators) among newborns with meningitis (hospital days, 37 versus 23; intensive care unit [ICU], 97% versus 64%; expenditures, US $423,390 versus $168,861) and sepsis (hospital days, 18 versus 14; ICU, 93% versus 52%; expenditures, $139,973 versus $78,549). Mean levels during the 1-year follow-up period were also markedly higher (versus comparators) among newborns with meningitis (expenditures: by $218,464) or sepsis (expenditures: by $39,259).

Conclusions

Serious bacterial infections among newborns place a substantial burden on the US healthcare system for the treatment of acute illness as well as long-term complications. Interventions targeting the prevention of newborn bacterial infections have the potential to yield significant resource utilization and cost offsets.