<p>This study presents the dynamic soil-pile structure interaction (SSPSI) of a 15-story symmetric building frame resting on different pile configurations and provided with damping layers for studying the performance of such building under earthquake. The seismic data from the Bhuj (India) earthquake occurred in 2001 is used in this study. The present study investigates as to how different pile arrangements affects seismic soil-pile structure interaction under real-world seismic conditions. A three-dimensional finite element model of the building frame with realistic soil and foundation properties is developed which accounts for both elastic soil with linear interface conditions and elastic soil with nonlinear interface conditions. Damping layers with increasing damping around the soil medium is introduced to absorb seismic energy, reduce resonance effects, and enhance the structures resilience. Dynamic loading scenarios subject the model to key response parameters such as lateral displacement, maximum deformation, inter-story drift, and base shear. The results show that the addition of the damping layers and different types of piles greatly reduces the stress that earthquakes put on the structure by releasing vibrational energy. Different pile configurations and linear and nonlinear soil-structure interfaces show different response behaviour. This shows the significance of modelling both- the soil and the foundation, in excellent detail. The results indicate further that dynamic SSI analysis, the right pile configurations, and the damping mechanisms are important for making high-rise buildings structurally more resilient in areas prone to earthquakes where the ground is soft or flexible.</p>