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<p>Proton minibeam radiation therapy (pMBRT) has emerged as a promising radiation treatment modality, offering enhanced tissue-sparing effects compared to conventional proton therapy. For clinical application, we developed a pMBRT system with the largest field size (30 × 40 cm2) in the world, and conducted a comprehensive dosimetric evaluation of its characteristics. Our system consists of a large-area multi-slit collimator (MSC), a depth-dose modulator, a neutron absorber, a range shifter, and a custom snout compatible with the conventional proton therapy machines. We investigated two energy conditions (170&#xa0;MeV with and 200&#xa0;MeV without a range shifter), varying air gap and scatterer configurations to simulate clinical treatments. Lateral dose profiles showed peak and valley dose standard deviations below 5.5% of their respective means. Analysis of scatterer characteristics using the peak-to-valley dose ratio (PVDR) showed that as scatterer thickness increased, the PVDR approached 1 just beneath the phantom surface. Conversely, under low-scattering conditions, the PVDR at the phantom surface exceeded 15. For shallow tumors, a high PVDR at the surface is desired, with a rapid decrease near the tumor's depth. The depth-dose modulation effect was analyzed using air gaps and lead scatterers to amplify multiple Coulomb scattering. Monte Carlo simulations confirmed a significant reduction in secondary neutrons due to the neutron absorber. In conclusion, our system generates minibeams with a uniform dose envelope. Excellent depth-dose modulation using scatterers facilitates simultaneous skin protection and shallow-depth tumor treatment. By mitigating secondary neutrons, the system can also reduce radiation toxicity, enhancing its clinical viability.</p>

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Dosimetric evaluation of large-area proton minibeam radiation therapy system for clinical applications

  • 期刊论文

  • 发表日期：

    2025年6月10日

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  • Jusung Kim,
  • Kyeongyun Park,
  • Dohyeon Kim,
  • Hak Soo Kim,
  • Chankyu Kim,
  • Jong Hwi Jeong,
  • Dongho Shin,
  • Se Byeong Lee,
  • Myeongsoo Kim,
  • Tae Hyun Kim,
  • Young Kyung Lim

摘要

Proton minibeam radiation therapy (pMBRT) has emerged as a promising radiation treatment modality, offering enhanced tissue-sparing effects compared to conventional proton therapy. For clinical application, we developed a pMBRT system with the largest field size (30 × 40 cm2) in the world, and conducted a comprehensive dosimetric evaluation of its characteristics. Our system consists of a large-area multi-slit collimator (MSC), a depth-dose modulator, a neutron absorber, a range shifter, and a custom snout compatible with the conventional proton therapy machines. We investigated two energy conditions (170 MeV with and 200 MeV without a range shifter), varying air gap and scatterer configurations to simulate clinical treatments. Lateral dose profiles showed peak and valley dose standard deviations below 5.5% of their respective means. Analysis of scatterer characteristics using the peak-to-valley dose ratio (PVDR) showed that as scatterer thickness increased, the PVDR approached 1 just beneath the phantom surface. Conversely, under low-scattering conditions, the PVDR at the phantom surface exceeded 15. For shallow tumors, a high PVDR at the surface is desired, with a rapid decrease near the tumor's depth. The depth-dose modulation effect was analyzed using air gaps and lead scatterers to amplify multiple Coulomb scattering. Monte Carlo simulations confirmed a significant reduction in secondary neutrons due to the neutron absorber. In conclusion, our system generates minibeams with a uniform dose envelope. Excellent depth-dose modulation using scatterers facilitates simultaneous skin protection and shallow-depth tumor treatment. By mitigating secondary neutrons, the system can also reduce radiation toxicity, enhancing its clinical viability.